Platelet to lymphocyte ratio and neutrophil to lymphocyte ratio in patients with rheumatoid arthritis

• Autorzy: You-Fan Peng , Ling Cao , Yan-Hua Zeng , Zhao-Xia Zhang , Dan Chen , Qiong Zhang , You-Sen Zhu
• Języki publikacji: EN

Abstrakty

EN

Objectives: It has been well documented that the platelet to lymphocyte ratio (PLR) and the neutrophil to lymphocyte ratio (NLR) are associated with outcomes for patients with gastric cancer, non-small cell lung cancer and acute heart failure. Inflammation may be the hidden factor that explains the correlation between NLP, PLR, and these diseases. However, to date, the data concerning NLR, PLR, and its association with inflammation are lacking in patients with rheumatoid arthritis (RA), thus, our aim to discuss whether NLR and PLR are associated with RA. Methods: Patients with RA and healthy individuals were included according to the determined criteria, and laboratory indicators were measured. Results: PLR and NLR were significantly higher in RA patients compared with healthy controls (3.20±2.06 vs. 1.56±0.47, P<0.01; 192.85±101.78 vs. 103.49±28.68, P<0.01). When leukocytes, neutrophil percentage, neutrophil, lymphocyte, platelet, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and rheumatoid factor (RF) were considered as confounders (crude model), our results indicated that ESR and RF were correlated to RA. Of note, ESR, RF, and PLR were associated with RA after further adjustment based on crude model for PLR and NLR. Receiver operating characteristic (ROC) curves analysis showed that PLR values higher than >115.7 evaluated RA with a sensitivity of 82.5%, a specificity of 74.8% and area under the curve ( AUC ) of 0.847. Conclusions:Our results suggest that PLR is associated with RA, and PLR may be an underlying indicator indicating the chronic subclinical inflammation in patients with RA.

Słowa kluczowe

EN

Rheumatoid arthritis; platelet to lymphocyteratio; neutrophil to lymphocyte ratio; subclinicalinflammation

• Czasopismo: Open Medicine
• Rocznik: 2014
• Tom: 10
• Numer: 1

Daty

zaakceptowano

2014-03-13

otrzymano

2014-11-27

online

2015-04-14

Twórcy

autor

You-Fan Peng

• Laboratory Medicine Diagnostic Centre, The
  First Affiliated Hospital, Xin Jiang Medical University, Xinjiang Urumqi,
  China

autor

Ling Cao

• Laboratory Medicine Diagnostic Centre, The
  First Affiliated Hospital, Xin Jiang Medical University, Xinjiang Urumqi,
  China

autor

Yan-Hua Zeng

• Laboratory Medicine Diagnostic Centre, The
  First Affiliated Hospital, Xin Jiang Medical University, Xinjiang Urumqi,
  China

autor

Zhao-Xia Zhang

• Laboratory Medicine Diagnostic Centre, The
  First Affiliated Hospital, Xin Jiang Medical University, Xinjiang Urumqi,
  China

autor

Dan Chen

• Department of Rheumatology, The First Affiliated Hospital,
  Xin Jiang Medical University

autor

Qiong Zhang

• Laboratory Medicine Diagnostic Centre, The
  First Affiliated Hospital, Xin Jiang Medical University, Xinjiang Urumqi,
  China

autor

You-Sen Zhu

• The First Affiliated Hospital,
  Xin Jiang Medical University, No.1-137, Liyushan Road, Xin’shi Region,
  Urumqi.XinJiang, China 830011

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Identyfikatory

DOI

10.1515/med-2015-0037