Correlation between SNPs in CDH1 and gastric cancer in Chinese population

• Autorzy: Yijin Lin , Jintao Yuan , Lihui Wang , Lan Wang , Yunjia Ma , Yuhua Wang , Jianhong Chen , Hong Zhao
• Języki publikacji: EN

Abstrakty

EN

Background. Many recent studies revealed that the single nucleotide polymorphisms have considerable effects on the susceptibility of cancer, such as prostate cancer, lung cancer and gastric cancer. The E-cadherin, a calcium-dependent transmembrane glycoprotein encoded by CDH1 gene, is critical for epithelial construction, intercellular adhesion and cell migration. Some associations have been reported between single nucleotide polymorphisms and gastric cancer in the Chinese population. Objective. To investigate whether the single nucleotide polymorphism in CDH1 gene is associated with the susceptibility of gastric cancer in the Chinese population. Material and methods. The genotypes of 5 known single nucleotide polymorphisms (rs33935154, rs121964871, rs121964874, rs121964875, rs121964876) were determined in 359 gastric cancer patients and 368 healthy controls. High resolution melting curve detection and sequencing analysis were used in the present study. Results. There is a statistical significance in the rs121964871 C>G polymorphism between gastric cancer patients and healthy controls (OR=1.769, 95%CI: 1.051-2.976). Elderly male individuals (>50 years of age) carrying this risk factor may be more susceptible to gastric cancer. Conclusions. The results indicated that the rs121964871 C>G polymorphism is associated with the susceptibility of gastric cancer in the Chinese population, with some age and sex-dependent tendencies observed.

Słowa kluczowe

EN

Single nucleotide polymorphism; Gastric cancer; CDH1 gene

• Czasopismo: Open Medicine
• Rocznik: 2014
• Tom: 10
• Numer: 1

Daty

wydano

2015-01-01

otrzymano

2014-07-20

zaakceptowano

2014-08-28

online

2014-11-03

Twórcy

autor

Yijin Lin

• Danyang People’s Hospital of
  Jiangsu Province, Danyang, China, Danyang Hospital affiliated to
  Nantong University, Danyang, Jiangsu 212300, China

autor

Jintao Yuan

• Danyang People’s Hospital of
  Jiangsu Province, Danyang, China, Danyang Hospital affiliated to
  Nantong University, Danyang, Jiangsu 212300, China

autor

Lihui Wang

• Danyang People’s Hospital of
  Jiangsu Province, Danyang, China, Danyang Hospital affiliated to
  Nantong University, Danyang, Jiangsu 212300, China

autor

Lan Wang

• Danyang Blood Center of Jiangsu Province, Danyang,
  Jiangsu 212300, China

autor

Yunjia Ma

• Danyang People’s Hospital of
  Jiangsu Province, Danyang, China, Danyang Hospital affiliated to
  Nantong University, Danyang, Jiangsu 212300, China

autor

Yuhua Wang

• Danyang People’s Hospital of
  Jiangsu Province, Danyang, China, Danyang Hospital affiliated to
  Nantong University, Danyang, Jiangsu 212300, China

autor

Jianhong Chen

• Danyang People’s Hospital of
  Jiangsu Province, Danyang, China, Danyang Hospital affiliated to
  Nantong University, Danyang, Jiangsu 212300, China

autor

Hong Zhao

• Danyang People’s Hospital of
  Jiangsu Province, Danyang, China, Danyang Hospital affiliated to
  Nantong University, Danyang, Jiangsu 212300, China

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Identyfikatory

DOI

10.1515/med-2015-0007