Insulin resistance and adipokine levels correlate with early atherosclerosis – a study in prediabetic patients

• Autorzy: Bogdan Mircea Mihai , Antoniu Octavian Petriș , Didona Anca Ungureanu , Cristina Mihaela Lăcătușu
• Języki publikacji: EN

Abstrakty

EN

Cardiovascular risk of prediabetes is still subject to controversies. We analyzed the associations between insulin resistance, adipokines and incipient atherosclerosis estimated by intima-media thickness (IMT) in a cross-sectional study on 122 prediabetic subjects without clinical signs of atherosclerotic disease. Homeostasis model assessment of insulin resistance (HOMA-IR, calculated as fasting insulin × fasting plasma glucose / 22.5), adiponectin, leptin, leptin-to-adiponectin ratio, carotid and femoral IMT were evaluated. We also assessed other parameters related to insulin resistance and adipokines (HbA1c, anthropometric and lipid parameters), as they may also influence atherosclerosis. Carotid IMT was correlated to adiponectin and leptin-to-adiponectin ratio (all p < 0.05), but not with HOMA-IR or leptin, while femoral IMT showed no relationship with these factors. After adjusting for leptin, leptin-to-adiponectin ratio, triglycerides, HDL-cholesterol, cholesterol-to-HDL ratio, triglycerides-to-HDL ratio and HbA1c, IMT values became correlated with HOMA-IR. Adjustment for HOMA-IR induced the appearance of new correlations between adipokines and both IMT values. In conclusion, insulin resistance and adipokines seem related to IMT in prediabetic subjects without clinical signs of arterial obstruction.

Słowa kluczowe

EN

prediabetes; insulin resistance; adiponectin; leptin; intima-media thickness

• Czasopismo: Open Medicine
• Rocznik: 2014
• Tom: 10
• Numer: 1

Daty

otrzymano

2014-01-14

zaakceptowano

2014-07-21

online

2014-09-26

Twórcy

autor

Bogdan Mircea Mihai

• Discipline of Diabetes, Nutrition and Metabolic Diseases, First Medical Department, University of Medicine and Pharmacy ”Grigore T. Popa”, 16th Universității Street, 700115, Iași, Romania

autor

Antoniu Octavian Petriș

• Discipline of Internal Medicine and Cardiology, First Medical Department, University of Medicine and Pharmacy ”Grigore T. Popa”, 16th Universității Street, 700115, Iași, Romania

autor

Didona Anca Ungureanu

• Discipline of Biochemistry, Morpho-Functional Sciences Department, University of Medicine and Pharmacy ”Grigore T. Popa”, 16th Universității Street, 700115, Iași, Romania

autor

Cristina Mihaela Lăcătușu

• Discipline of Diabetes, Nutrition and Metabolic Diseases, First Medical Department, University of Medicine and Pharmacy ”Grigore T. Popa”, 16th Universității Street, 700115, Iași, Romania

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Identyfikatory

DOI

10.1515/med-2015-0003