The effect of glycemic control on CEA, CA 19-9, amylase and lipase levels

• Autorzy: Naim Ata , Kürşat Dal , Metin Kucukazman , Abdullah Ö. Yeniova , Serdar Karakaya , Oktay Unsal , Murat Dagdeviren , Kadir O. Akın , Salih Baser , Esin Beyan , Derun T. Ertugrul
• Języki publikacji: EN

Abstrakty

EN

Background: Diabetes mellitus is closely related to pancreas cancer. In this study we aimed to investigate the effect of hyperglycemia on tumor and inflammation markers, as well as pancreatic exocrine functions.Methods: A total of 98 consecutive diabetic patients with poor glycemic control, and 50 healthy controls were included in the study. We measured hsCRP, erythrocyte sedimentation rate (ESR), CA19-9, CEA, amylase and lipase in addition to routine biochemistry tests, before and after euglycemia was achieved.Results: Fasting blood glucose, HbA1c, CA19-9,CEA, hsCRP, ESR, triglycerides, AST, ALT, GGT, ALP, total cholesterol and LDL-C levels decreased significantly with the regulation of glycemic control. Amylase and lipase levels increased with the regulation of glycemic control. After glycemic control, CA19-9 and CEA levels were still higher, whereas amylase and lipase levels were still lower in the diabetic group compared with the control group. Basal HbA1c showed significant correlation with CA19-9, CEA, amylaseand lipase.Conclusions: We propose to repeat observations of tumor markers after hyperglycemia is resolved, in order to avoid unnecessary invasive tests. Our data also suggest that pancreatic exocrine function was improved with lowering blood glucose in a short period of time.

Słowa kluczowe

EN

Glycemic control; CA19-9; CEA; amylase; lipase

• Czasopismo: Open Medicine
• Rocznik: 2014
• Tom: 10
• Numer: 1

Daty

otrzymano

2014-03-30

zaakceptowano

2014-07-29

online

2014-09-17

Twórcy

autor

Naim Ata

• Kecioren Training and Research Hospital, Department of Internal Medicine. Ardahan street. No:2506380 Keçiören, Ankara, Turkey

autor

Kürşat Dal

• Kecioren Training and Research Hospital, Department of Internal Medicine. Ardahan street. No:2506380 Keçiören, Ankara, Turkey

autor

Metin Kucukazman

• Kecioren Training and Research Hospital, Department of Internal Medicine. Ardahan street. No:2506380 Keçiören, Ankara, Turkey

autor

Abdullah Ö. Yeniova

• Kecioren Training and Research Hospital, Department of Internal Medicine. Ardahan street. No:2506380 Keçiören, Ankara, Turkey,

autor

Serdar Karakaya

• Kecioren Training and Research Hospital, Department of Internal Medicine. Ardahan street. No:2506380 Keçiören, Ankara, Turkey

autor

Oktay Unsal

• Kecioren Training and Research Hospital, Department of Internal Medicine. Ardahan street. No:2506380 Keçiören, Ankara, Turkey

autor

Murat Dagdeviren

• Kecioren Training and Research Hospital, Department of Internal Medicine. Ardahan street. No:2506380 Keçiören, Ankara, Turkey

autor

Kadir O. Akın

• Kecioren Training and Research Hospital, Department of Clinical Biochemistry. Ardahan street. No:2506380 Keçiören, Ankara, Turkey

autor

Salih Baser

• Kecioren Training and Research Hospital, Department of Internal Medicine. Ardahan street. No:2506380 Keçiören, Ankara, Turkey

autor

Esin Beyan

• Kecioren Training and Research Hospital, Department of Internal Medicine. Ardahan street. No:2506380 Keçiören, Ankara, Turkey

autor

Derun T. Ertugrul

• Kecioren Training and Research Hospital, Department of Internal Medicine. Ardahan street. No:2506380 Keçiören, Ankara, Turkey

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Identyfikatory

DOI

10.1515/med-2015-0002