Possible involvement of endoplasmic reticulum stress in the pathogenesis of Alzheimer’s disease

• Autorzy: Toru Hosoi , Jun Nomura , Koichiro Ozawa , Akinori Nishi , Yasuyuki Nomura
• Języki publikacji: EN

Abstrakty

EN

The endoplasmic reticulum (ER) is an organelle that plays a crucial role in protein quality control such as protein folding. Evidence to indicate the involvement of ER in maintaining cellular homeostasis is increasing. However, when cells are exposed to stressful conditions, which perturb ER function, unfolded proteins accumulate leading to ER stress. Cells then activate the unfolded protein response (UPR) to cope with this stressful condition. In the present review, we will discuss and summarize recent advances in research on the basic mechanisms of the UPR. We also discuss the possible involvement of ER stress in the pathogenesis of Alzheimer’s disease (AD). Potential therapeutic opportunities for diseases targeting ER stress is also described.

Słowa kluczowe

EN

Alzheimer’s disease; pathogenesis; therapeutics development; endoplasmic reticulum stress; unfolded protein response

• Czasopismo: Endoplasmic Reticulum Stress in Diseases
• Rocznik: 2015
• Tom: 2
• Numer: 1

Daty

otrzymano

2015-06-30

zaakceptowano

2015-09-01

online

2015-10-19

Twórcy

autor

Toru Hosoi

• Department of Pharmacotherapy,
  Graduate School of Biomedical and Health Sciences, Hiroshima
  University, Hiroshima 734-8553, Japan

autor

Jun Nomura

• Department of Biomedical Research, Graduate School
  of Biomedical and Health Sciences, Hiroshima University, Hiroshima
  734-8553, Japan

autor

Koichiro Ozawa

• Department of Pharmacotherapy,
  Graduate School of Biomedical and Health Sciences, Hiroshima
  University, Hiroshima 734-8553, Japan

autor

Akinori Nishi

• Department of
  Pharmacology, Kurume University School of Medicine, Kurume,
  Fukuoka 830-0011, Japan

autor

Yasuyuki Nomura

• Department of
  Pharmacology, Kurume University School of Medicine, Kurume,
  Fukuoka 830-0011, Japan

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Identyfikatory

DOI

10.1515/ersc-2015-0008