Centaurea cyanusL. Polysaccharides and Polyphenols Cooperation in Achieving Strong Rat Gastric Ulcer Protection

• Autorzy: Lucia Pirvu , Corina Bubueanu , Minerva Panteli , Lucian Petcu , Dragomir Coprean
• Języki publikacji: EN

Abstrakty

EN

This work was aimed at testing gastroprotective effects of Centaurea cyanus L. (herba) polysaccharides (P) and polyphenols (A) fractions on stress-induced rat ulcer model. Studies evaluating acute toxicity in rats and antioxidant (chemiluminescence method) and antimicrobial (on Staphylococcus aureus ATCC6538 and Escherichia coli ATCC8739 strains) activities of Centaurea cyanus L. (herba) product, which combined polysaccharides and polyphenols fractions (PA), have also been done. Accordingly, in vivo pharmacological studies revealed high influence of PA product (500 mg kg-1 of body weight) on deep, moderate and superficial gastric mucosal lesions, greater than that of chemical reference, Ranitidine. P product was proven more effective than Ranitidine in opposing the emergence of deep necrotic lesions only, suggesting the ability of polysaccharides compounds to consolidate gastric mucous layer as well as their certain tendency for cooperation with polyphenols fractions. The acute toxicity study indicated the lack of toxicity of PA product and maximum tolerated doses greater than 1875 mg kg-1 of body weight. PA product provided augmented scavenger activity and week antimicrobial activity on Staphylococcus aureus ATCC6538 and Escherichia coli ATCC8739 strains, resulting in better opportunities for valorisation of the aerial part of Centaurea cyanus L. species in order to obtain new and effective natural medicines.

Słowa kluczowe

EN

cornflower; gastroprotective; antimicrobial; acute toxicity

• Czasopismo: Open Chemistry
• Rocznik: 2015
• Tom: 13
• Numer: 1

Daty

otrzymano

2014-12-17

zaakceptowano

2015-03-01

online

2015-05-26

Twórcy

autor

Lucia Pirvu

• National Institute for Chemical-
  Pharmaceutical Research and Development (ICCF), Vitan 112,
  Sector 3, Bucharest, Romania

autor

Corina Bubueanu

• National Institute for Chemical-
  Pharmaceutical Research and Development (ICCF), Vitan 112,
  Sector 3, Bucharest, Romania

autor

Minerva Panteli

• National Institute for Chemical-
  Pharmaceutical Research and Development (ICCF), Vitan 112,
  Sector 3, Bucharest, Romania

autor

Lucian Petcu

• OVIDIUS University – Constanta,
  Mamaia 124, Constanta, Romania

autor

Dragomir Coprean

• OVIDIUS University – Constanta,
  Mamaia 124, Constanta, Romania
• Academy of Romanian Scientists, Splaiul
  Independentei 54, Bucharest, Romania

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Identyfikatory

DOI

10.1515/chem-2015-0102