Non-thermal plasma treatment induces MAPK signaling in human monocytes

• Autorzy: Lena Bundscherer , Stefanie Nagel , Sybille Hasse , Helena Tresp , Kristian Wende , Reinhard Walther , Stephan Reuter , Klaus-Dieter Weltmann , Kai Masur , Ulrike Lindequist
• Języki publikacji: EN

Abstrakty

EN

The application of non-thermal atmospheric pressure plasma raises a hope for the new wound healing strategies. Next to its antibacterial effect it is known to stimulate skin cells. However, monocytes are also needed for the complex process of a wound healing. This study investigates the impact of plasma on the intracellular signaling events in the primary human monocytes. The proliferative MEK-ERK (MAPK/ERK kinase-extracellular signal-regulated kinase) pathway was activated by short plasma treatment times. In contrast, an induction of the apoptotic JNK (c-Jun N-terminal kinase) cascade as well as activation of caspase 3 were observed after long plasma exposure. These findings indicate that monocytes can be differentially stimulated by plasma treatment and may contribute to the proper wound recovery.

EN

Słowa kluczowe

EN

human monocytes; MAPK signaling; non-thermal plasma; plasma medicine; wound healing

• Czasopismo: Open Chemistry
• Rocznik: 2015
• Tom: 13
• Numer: 1

Daty

otrzymano

2014-01-07

zaakceptowano

2014-06-24

online

2014-12-30

Twórcy

autor

Lena Bundscherer

• Leibniz Institute
  for Plasma Science and Technology (INP Greifswald e.V.), Felix-
  Hausdorff-Str. 2, 17489 Greifswald, Germany

autor

Stefanie Nagel

• Leibniz Institute
  for Plasma Science and Technology (INP Greifswald e.V.), Felix-
  Hausdorff-Str. 2, 17489 Greifswald, Germany

autor

Sybille Hasse

• Leibniz Institute
  for Plasma Science and Technology (INP Greifswald e.V.), Felix-
  Hausdorff-Str. 2, 17489 Greifswald, Germany

autor

Helena Tresp

• Leibniz Institute
  for Plasma Science and Technology (INP Greifswald e.V.), Felix-
  Hausdorff-Str. 2, 17489 Greifswald, Germany

autor

Kristian Wende

• Leibniz Institute
  for Plasma Science and Technology (INP Greifswald e.V.), Felix-
  Hausdorff-Str. 2, 17489 Greifswald, Germany

autor

Reinhard Walther

• Institute for Medical Biochemistry and Molecular
  Biology, University of Greifswald, Ferdinand-Sauerbruch-Straße /
  Klinikum DZ 7, 17489 Greifswald, Germany

autor

Stephan Reuter

• Leibniz Institute
  for Plasma Science and Technology (INP Greifswald e.V.), Felix-
  Hausdorff-Str. 2, 17489 Greifswald, Germany

autor

Klaus-Dieter Weltmann

• Leibniz Institute
  for Plasma Science and Technology (INP Greifswald e.V.), Felix-
  Hausdorff-Str. 2, 17489 Greifswald, Germany

autor

Kai Masur

• Leibniz Institute
  for Plasma Science and Technology (INP Greifswald e.V.), Felix-
  Hausdorff-Str. 2, 17489 Greifswald, Germany

autor

Ulrike Lindequist

• Institute of Pharmacy, Department of
  Pharmaceutical Biology, University of Greifswald, Friedrich-Ludwig-
  Jahn-Str. 17, 17489 Greifswald, Germany

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Identyfikatory

DOI

10.1515/chem-2015-0071