Immunoactive ionic liquids based on 2-hydroxyethylamines and 1-R-indol-3-ylsulfanylacetic acids. Crystal and molecular structure of immunodepressant tris-(2-hydroxyethyl)ammonium indol-3-ylsulfanylacetate

• Autorzy: Anna N. Mirskova , Sergey N. Adamovich , Rudolf G. Mirskov , Olga P. Kolesnikova , Uwe Schilde
• Języki publikacji: EN

Abstrakty

EN

Immunoactive ionic liquids (2-hydroxyethyl)ammonium 1-R-indol-3-ylsulfanyl-acetates HN+R1R2(CH2CH2OH) ∙ -O(O)CCH2S-Ind-R3-1 (1-5), were synthesized by the reaction of (2-hydroxyethyl)amines with indol-3-ylsulfanylacetic- or 1-benzylindol-3-ylsulfanylacetic acid. 1: R1 = R2 = CH2CH2OH, R3 = H; 2: R1 = СН3,R2=CH2CH2OH, R3 = H; 3: R1 = R2 = CH3, R3 = H; 4: R1 = R2 = CH2CH2OH, R3 = СH2С6Н5; 5: R1 = СН3; R2 = CH2CH2OH; R3 = СH2С6Н5. The structure of each compound was elucidated by IR, NMR 1H, 13С, and 15N techniques and their composition was confirmed by elemental analysis. The crystal structure of tris-(2-hydroxyethyl) ammonium indol-3-ylsulfanylacetate was investigated by X-ray diffraction analysis. Immunoactive properties of the title compounds were screened.

EN

Słowa kluczowe

EN

Protic 2-hydroxyethylammonium ionic liquids; 2-Hydroxyethylammonium 1-R-indol-3-ylsulfanylacetates; Crystal and molecular structure; Immunoactive properties

• Czasopismo: Open Chemistry
• Rocznik: 2015
• Tom: 13
• Numer: 1

Daty

otrzymano

2014-04-15

zaakceptowano

2014-06-17

online

2014-11-01

Twórcy

autor

Anna N. Mirskova

• A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences, 664033 Irkutsk, Russia

autor

Sergey N. Adamovich

• A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences, 664033 Irkutsk, Russia

autor

Rudolf G. Mirskov

• A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences, 664033 Irkutsk, Russia

autor

Olga P. Kolesnikova

• Research Institute of Clinical Immunology, Siberian Branch of the Russian Academy of Medical Sciences, 630099 Novosibirsk, Russia

autor

Uwe Schilde

• Institute of Chemistry, University of Potsdam, D-14476 Potsdam, Germany

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Identyfikatory

DOI

10.1515/chem-2015-0018