Antibacterial, DNA photocleavage and molecular docking studies of newly prepared Schiff-based macrocyclic complexes

• Authors: Purti Mishra , Pooja Sethi , Selva Kumar Ramasamy , Adesh K. Saini , Hardeep Singh Tuli , Divya Mittal , Aarti Trehan

Abstracts

EN

Introduction and aim. At present, several microbial diseases are prominent and of concern worldwide. The intent of this study was to examine the antibacterial potential of newly synthesized tetradentate macrocyclic complexes against different bacterial strains. The macrocyclic scaffold has gained attention as a biologically active class of supramolecular chemistry due to its unique properties and ability to target various microorganisms. Thus, the goal of the present study was to develop a series of biologically active transition metal-based macrocycles. Material and methods. All macrocyclic compounds were synthesized by a template method and validated by molar conductivity, elemental studies, and spectral and magnetic studies. Antibacterial activities of all metal complexes were evaluated against Escherichia coli (MTCC 739) and Staphylococcus aureus (MTCC 731) bacterial strains by taking ampicillin as a standard reference drug. DNA photocleavage potential was explored using agarose gel electrophoresis. Results. Results revealed the formation of novel macrocyclic complexes via tetra nitrogen bond trapping of metals. Copper complexes have strong potential against S. aureus bacteria as copper and nickel both show good DNA photocleavage potential. Conclusion. The findings endorse the biomedical relevance of these macrocyclic scaffolds, suggesting avenues for further exploration in targeted drug delivery and potential clinical applications. The proposed octahedral geometry for the complexes enhances our understanding of their structural aspects. This research contributes substantively to the field, laying the foundation for future investigations in advanced antimicrobial design and application.

Keywords

EN

anti-bacterial; DFT; DNA photocleavage; molecular docking; template method

• Publisher: Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
• Journal: European Journal of Clinical and Experimental Medicine
• Year: 2024
• Volume: 22
• Issue: 1
• Pages: 154-163

Dates

published

2024

Contributors

author

Purti Mishra

• Department of Chemistry, MMEC, Maharishi Markandeshwar (Deemed to be University), Haryana, India

author

Pooja Sethi

• Department of Chemistry, MMEC, Maharishi Markandeshwar (Deemed to be University), Haryana, India

author

Selva Kumar Ramasamy

• Department of Chemistry, MMEC, Maharishi Markandeshwar (Deemed to be University), Haryana, India

author

Adesh K. Saini

• Department of Bio-Sciences and Technology, MMEC, Maharishi Markandeshwar (Deemed to be University), Haryana, India

author

Hardeep Singh Tuli

• Department of Bio-Sciences and Technology, MMEC, Maharishi Markandeshwar (Deemed to be University), Haryana, India

author

Divya Mittal

• Faculty of Agriculture, Maharishi Markandeshwar (Deemed to be University), Haryana, India

author

Aarti Trehan

• Department of Chemistry, Arya Kanya Mahavidyalya, Shahabad Markanda, Haryana, India

Identifiers

DOI

10.15584/ejcem.2024.1.27

Biblioteka Nauki

40422849