Assessment of serum creatinine, urea, and aminotransferase levels among methamphetamine addicted individuals in Khartoum State

• Authors: Al-Noor Opied Al-Tayeb , Mohammed Hayati Abubakr , Hafsa Ahmed Elrheima , Ahmed Khalid Habbani , Rami Y. Hassab Elrasul

Abstracts

EN

Introduction and aim. Methamphetamine-use disorder is a pressing global public health issue. In Sudan, the escalating methamphetamine (METH) consumption has become a significant social and health problem. This study aims to evaluate liver and kidney biomarkers in methamphetamine addicts in Khartoum state. Material and methods. The study was an analytical prospective cross-sectional hospital-based study. One hundred participants were enrolled in this study, fifty were cases (methamphetamine addicts), and others were healthy non-METH users as a comparative group. Results. METH users had a mean age of (27±7) years and had been using METH for an average of (14±9) months. Urea and creatinine levels were also significantly elevated in METH users compared to non-users, with p<0.001 and p=0.044, respectively. Their aspartate transaminase (AST) and alanine transaminase (ALT) levels were significantly higher compared to non-users, with p<0.001. Conclusion. There was significant increases in creatinine, urea, and aminotransferases levels in the case group. ALT showed a moderate positive correlation with abuse duration, while AST showed no significant correlation. Urea and creatinine levels had strong and moderate positive correlations with abuse duration, respectively.

Keywords

EN

aminotransferases; creatinine; methamphetamine; urea

• Publisher: Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
• Journal: European Journal of Clinical and Experimental Medicine
• Year: 2024
• Volume: 22
• Issue: 1
• Pages: 68-72

Dates

published

2024

Contributors

author

Al-Noor Opied Al-Tayeb

• Chemical Pathology Department, Faculty of Medical Laboratory Science, University of Medical Sciences and Technology, Khartoum, Sudan

author

Mohammed Hayati Abubakr

• Chemical Pathology Department, Faculty of Medical Laboratory Science, University of Medical Sciences and Technology, Khartoum, Sudan

author

Hafsa Ahmed Elrheima

• Chemical Pathology Department, Faculty of Medical Laboratory Science, University of Medical Sciences and Technology, Khartoum, Sudan

author

Ahmed Khalid Habbani

• Histopathology and Cytology Department, Faculty of Medical Laboratory Science, University of Medical Sciences and Technology, Khartoum, Sudan

author

Rami Y. Hassab Elrasul

• Biostatistics, Faculty of Medical Laboratory Science, Nepta College, Khartoum, Sudan

Identifiers

DOI

10.15584/ejcem.2024.1.10

Biblioteka Nauki

38695722