In this article, a new problem that is called system of split mixed equilibrium problems is introduced. This problem is more general than many other equilibrium problems such as problems of system of equilibrium, system of split equilibrium, split mixed equilibrium, and system of split variational inequality. A new iterative algorithm is proposed, and it is shown that it satisfies the weak convergence conditions for nonexpansive mappings in real Hilbert spaces. Also, an application to system of split variational inequality problems and a numeric example are given to show the efficiency of the results. Finally, we compare its rate of convergence other algorithms and show that the proposed method converges faster.