The utilization of laser is wide and namely in the field of heat cutting of materials where this method is the most progressive. The optimization of all parameters of cutting arrangement is the most important for achievement the best quality of cutting area; it means rate, power, pressure, and focal distance of laser. Suitable setting of various parameters can influence the quality of cutting area. The quality of specific cutting material is also considerable factor of cutting process. The finding optimal cutting conditions for achievement maximal cutting rate were the goal of this work. The setting of individual parameters was evaluated with regard to quality and heat affected cutting area. The carbon steel grade 11 373 and high-alloy Cr-Ni steel 17 240.2 were used for experiments. The quality and heat affected cutting area of individual materials were evaluated by means of measurements of roughness and metallographic evaluation and microhardness of heat affected zone.