Wyniki wyszukiwania - BazTech

Ograniczanie wyników

Znaleziono wyników: 3

Liczba wyników na stronie

Wyniki wyszukiwania

Wyszukiwano:
w słowach kluczowych: zastawka aorty

Sortuj według:

Ogranicz wyniki do:

The interaction of laser radiation with tissue in the aspect of generating the process of decellularization in the preparation of animal origin autologous tissue

Kopernik Magdalena, Major Roman, Lis Grzegorz, Wilczek Piotr, Lis Maciej, Imbir Gabriela, Chrouda Abir, Mzyk Aldona, Ostrowski Roman, Sanak Marek

Acta of Bioengineering and Biomechanics

2020

Vol. 22, no. 1

67--77

Purpose: The aim of the work was to create an appropriate substrate for organ transplantation using bioactive tissue-based scaffold populated by cells of the graft recipient. The purpose of the modeling was to investigate the mechanical effects of wave loading of aortic and pulmonary tissue material. Methods: The biological properties of tissues of aortic and pulmonary valves were modified by the process of decellularization. The host cells were removed by various physical methods with focus on minimal degradation of the extracellular matrix. Thus, the decellularization process was controlled by histological methods. The tissue decellularization process was simulated by finite element modelling. Results: The mechanical results represented by a displacement at the center of the sample were coherent and the heterogeneity of the distribution of the caves on the surface of the samples was confirmed, both by experiment and in the simulation by the alternate occurrence of local minima and maxima. The latter results from the uneven removal of cells from the effect of the wave causing decellularization were also predicted by the numerical model. Laser radiation had a destructive effect on the components of the extracellular matrix (e.g., collagen and elastic fibers), mainly depending on the fluence and number of pulses in a single exposure. Conclusions: The differences between the valve tissue materials were shown, and the impact of the process of decellularization on the properties of the tissues was analyzed. It should be emphasized that due to low absorption and high scattering, laser radiation can deeply penetrate the tissue, which allows for effective decellularization process in the entire volume of irradiated tissue.

Optimizing the shape of the prosthetic aortic leaflet valve

Konderla P., Patralski K.

Computer Assisted Mechanics and Engineering Sciences

2006

Vol. 13, No. 4

557-564

The object under study reported on in this paper was an aortic valve based on a natural aortic valve as the original. Simulations were carried out to examine the functioning of a valve which was loaded with varying pressure until a buckling of the leaflets and a fuli opening of the valve were observed. The aim of the study was the optimal choice of the geometrie and mechanical parameters for the class of construction assumed for analysis.

The analysis of heart valve dysfunction and effectiveness of disc-designed prostheses

Shilko S. V., Hizhenok V. F., Kuzminsky Yu. G., Salivonchik S. P.

Acta of Bioengineering and Biomechanics

2003

Vol. 5, no. 2

53-62

The function of heart (in good condition and in poor condition) and hemodynamic characteristics of mechanical prosthetic cardiac valves influencing hemolysis and blood coagulation have been investigated. The solid-state models of disc-designed prosthetic cardiac valves have been constructed. The finite element analysis of blood velocity and pressure at direct and inverse blood flows has shown better characteristics of bi-leaflet valves. The advantage of the numerical modelling is in the possibility of thorough description of blood flow with determination of turbulence and depression zones for different sizes, curvature and ultimate opening angle of leafs. It allows minimising hydraulic resistance, thrombus formation and hemolysis-preserving high reliability of valve closing. The individual design of valve is discussed and aimed at improving a valve function by creating the blood flow twisting.