In the current industrial scenarios those involved in production and services distribution are called to deal with a plurality of stakeholders, considering different interests, readings and positions. This paper exploits the concept of collaboration in this fast changes and flexible scenario by describing the characteristics of collaboration among enterprises and their scope. In this context, the purpose of all managers to maximize utility, to save cost or to minimize of transaction costs is hard to be reached. Under this prospective, to collaborate with other firms is a logical way to work and to pursue the previous objectives. The purpose of this paper is to define all the aspects of collaboration, mainly among enterprises, and the reasons that can drive a manager to stipulate a collaboration agreement. Two different ways, through collaboration can rise, have been described: collaboration induced by external body (top-down collaboration) or born in a spontaneous way (bottom-up). The management of the collaboration and the identification of key performance indicators, able to control the development of the network system, is addressed by exploiting the Italian network contract and the case study of the energy cluster.