The paper presents detailed geochemical survey of stream sediments in Zagożdżonka river system. The Zagożdżonka river drains agricultural areas and forests [Puszcza Kozienicka] and flows through towns-Pionki and Kozienice. The works [metallurgical, power plants, plastic materials, munitions-factory localized in towns put industrial and communal sewage into Zagożdżonka river. Active sediments (180 samples; <0.2 mm) were leached with HCl (1:4); then, using the ICP-AES method determinations were made the concentration of Ag, Al, As, Ba, Be, Ca, Cd, Co, Cr, Cu, Fe, Mg, Mn, Ni, P, Pb, S, Sr, Ti, V and Zn. Mercury concentration was measured using the CV-AAS method. The geochemical survey reveals that industrial plants activity are the main sources of anthropogenic pollution of stream sediments in Zagożdżonka river catchment. The strong local anomalies of As, Be, Ca, Cd, Cr, Cu, Hg, Ni, Pb, Sr, Ti and Zn near Pionki and Kozienice towns can be related to low efficiency of sewage treatment plants in metal removing.