In this paper the optimization methods to reduce undesirable effects in time-domain pre-emphasis techniques are described. In the first case the application of data-dependent method for pulse-width modulated (PWM) pre-emphasis to reduce additional jitter at output data stream is shown. Consequently, new signaling scheme based on using of raised cosine approximation to crosstalk reduction is proposed and analyzed. The time-domain pre-distortion method provides an alternative to FIR (finite impulse response) pre-emphasis with advantages in the light of developments in modern CMOS scaling. The PWM pre-emphasis method is able to compensate higher channel losses than the conventional FIR method. However additional high-frequency noise which is typical for strong amount of PWM pre-emphasis can caused system crosstalk susceptibility. Our research is primary focused on optimization of the conventional PWM scheme to reduce harmonic high frequency component. It can be solution for system where near-end crosstalk is problem. Finally, simulation results in MathCAD and Agilent ADS environment are shown.