This publication shows the issue of pilot’s and crew’s decision-making process to maintain safety connected with human factors in operation. The decision-making model is a very good indication, which should be used by pilots during air operations. The system is constructed according to decision-making loop which helps to select essential information and analyze current situation on aviation tasks, what in turn, allows quick and efficient planning of next operations and technical activities. One of the ways to upgrade effects of operation is to devise a decision-making model by integrating modern sciences (technique, economy, psychology, medicine etc.). The model of decision-making loop raises a common correlation between medical science and technical aspect. This model affects: - flight safety and security, - reliability, - economic use of aircraft. The decision-making process generally focuses on the interface between operators (pilots and crew) and helicopters systems, which are responsible for flight safety. Moreover, pilots and crew – helicopters systems performance also reflect the fallowing factors: - flight missions and requirements, - environmental constraints, - maintenance and operation of helicopter characteristics, - aviation instrumental equipment, - pilots and crew training. Thus, many essential elements of helicopters should be considered to optimize the roles of pilots and crew factors in total and complex systems. This recognition of pilots’ and crews’ properties is very important in helicopters design and operational procedures. Moreover, the proper level of helicopter survivability gives also more decision-making time for the crew during different visual flight conditions. Therefore, the range of manoeuvres and control requirements is wider because helicopters operate at very low terrain altitudes during operational activities of all crew. It is particularly difficult during failures of power system or navigation of helicopter.