In order to evaluate the water quality of the Hauterivian groundwater in the zinc deposit of Chaabet el Hamra, Southern Setif region, Algeria, eighteen physico-chemical parameters such as pH, EC, TDS, Cl−, SO42−, HCO3−, CO32−, NO3−, Ca2+, Mg2+, Na+, K+,, and heavy metals Zn, Pb, Fe, Cr, Cd, Mn were analyzed and collected from six different wells in April 2012. The studied groundwater is dominated by HCO3−, Ca2+, and Mg2+ ions. According to the World Health Organization (WHO) and Algerian standards, all groundwater samples are considered safe and fit for drinking as they fall within the permissible limits. In addition, the Schoeller diagram confirms the best quality water of the Hauterivian groundwater. Gibbs diagram show that the predominant samples fall in the rock-water interaction field, suggesting that water-rock interactions are the major mechanism controlling groundwater chemistry. Assessment of groundwater samples using various water quality indices such as sodium absorption ratio (SAR), soluble sodium percentage (SSP), residual sodium carbonate (RSC), magnesium hazard (MH) and Kelly ratio (KR) showed that the groundwater in the area has an excellent quality for irrigation purpose. According to Wilcox’s diagram, all groundwater samples fall in the C2S1 category, reflecting that they are suitable for irrigation.