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Zastosowania biologiczne tetrazoli i ich pochodnych

Olszewska A., Strzempek W.

Wiadomości Chemiczne

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2018

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[Z] 72, 3-4

207--228

EN

Due to the wide range of applications of tetrazoles, in recent years the number of publications and patents describing the synthesis, structural and physicochemical studies of compounds that contain tetrazole fragments in their structure has increased significantly [1]. Tetrazoles are unique compounds containing some of the most electron deficient aromatic rings so that they have one of the highest electron affinity [3]. They also have a whole range of coordination possibilities from simple monodentate ligands to complex polymer systems in which several of nitrogen atoms per tetrazole molecule are involved in the metal coordination. The presence of the metal allows a much wider application, combining the simple geometries and properties of organic compounds with the wealth of structure and properties of the metals. The discussed heterocyclic compounds are not only the most modern high energetic materials for military purposes [5], but also fungicides [6], herbicides [7], a promising component in many modern therapies [8] and drugs [11] (e.g. derivatives of indomethacin, drug for arthritis [1]). One of the most important fields in which tetrazoles and their derivatives are widely used is medicinal chemistry. Because of their high physiological activity and low toxicity, they are versatile in both biochemical and pharmaceutical applications [9]. Moreover, different compounds containing tetrazoles have antimicrobial (Fig. 1) [11, 13–17], antifungal (Fig. 2) [18–20], antiparasitic (Fig. 13–16) [34–36], antivirus (Fig. 17–19) [37–41], analgesic and anti-inflammatory (Fig. 3, 4) [17, 21–24], anti-epileptic, anticonvulsant (Fig. 10–13) [30–33], antihypertensive, antitumor (Fig. 5–9) [25–29], antidiabetic and other properties [12]. This article is a review of the selected tetrazoles and their derivatives in terms of their biological applications.

2

Wysokoenergetyczne tetrazole - potencjalne zamienniki azydku ołowiu

Wojewódka A., Witkowski T.

Chemik

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2013

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Vol. 67, nr 2

139-144

PL

Praca dotyczy analizy możliwości znalezienia zamiennika azydku ołowiu spośród pochodnych 1 H-tetrazolu i 5-aminotetrazolu. Przedstawiono metody syntezy tych związków oraz ich pochodnych. Przytoczono dane dotyczące standardowej entalpii tworzenia, wrażliwości na tarcie i uderzenie, a także wybrane parametry detonacji: ciśnienie (C-J) oraz prędkość.

EN

This paper describes the analysis of possibilities of finding the substitute for lead azide among the derivatives of 1H-tetrazole and 5-aminotetrazole. The synthesis methods of these compounds and their derivatives are presented. This paper presents the data on the standard enthalpy of formation, sensitivity to friction and impact as well as the data on the standard parameters of detonation: pressure (C-J) and velocity.

3

Wysokoenergetyczne tetrazole - potencjalne zamienniki azydku ołowiu

Wojewódka A., Witkowski T.

Chemik

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2013

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Vol. 67, nr 1

19-24

PL

Praca dotyczy analizy możliwości znalezienia zamiennika azydku ołowiu spośród pochodnych 1 H-tetrazolu i 5-aminotetrazolu. Przedstawiono metody syntezy tych związków oraz ich pochodnych. Przytoczono dane dotyczące standardowej entalpii tworzenia, wrażliwości na tarcie i uderzenie, a także wybrane parametry detonacji: ciśnienie (C-J) oraz prędkość.

EN

This paper describes the analysis of possibilities of finding the substitute for lead azide among the derivatives of 1H-tetrazole and 5-aminotetrazole. The synthesis methods of these compounds and their derivatives are presented. This paper presents the data on the standard enthalpy of formation, sensitivity to friction and impact as well as the data on the standard parameters of detonation: pressure (C-J) and velocity.

4

Energetic Nitrogen-Rich Polymers Based on Cellulose

Betzler F. M., Klapötke T. M., Sproll S.

Central European Journal of Energetic Materials

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2011

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Vol. 8, nr 3

157-171

EN

New nitrogen-rich polymers, based on cellulose, were synthesized using common procedures. The point of interest was the introduction of tetrazole and nitramine moieties. The polymers were characterized by elemental analysis and vibrational spectroscopy (IR). The energetic properties were investigated using differential scanning calorimetry and bomb calorimetric measurements. Several detonation parameters, such as the detonation pressure, velocity, energy and temperature were computed using the EXPLO5 code. In addition, the sensitivities towards impact and friction were tested using the BAM drophammer as well as a friction tester.