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Rola mikroRNA w farmakogenetyce - wybrane aspekty

Pamuła-Piłat J.

Laboratorium - Przegląd Ogólnopolski

2017

nr 7-8

32--35

MikroRNA (miRNA) to małe, niekodujące cząsteczki RNA mogące regulować ekspresję genów. Zmiany pojedynczych nukleotydów (SNPs) w genach miRNA mogą modulować interakcje pomiędzy miRNA a mRNA genów docelowych. Różnice międzyosobnicze odpowiedzi na chemioterapię mogą wynikać z modyfikacji ekspresji genów uczestniczących w reakcjach wchłaniania, dystrybucji, metabolizmu i wydalania leków.

MicroRNA (miRNA) is a small, non-coding RNA molecule capable of regulating gene expression. Single nucleotide polymorphisms (SNPs) in miRNA genes can modulate interactions between miRNA and mRNA of target genes. Interpersonal differences in response to chemotherapy may be due to the modifications in the expression of genes involved in the absorption, distribution, metabolism and excretion of drugs.

Modified S-transform as a tool to identify secondary structure elements in RNA

Singh N., Sharma S. D., Yennamalli R. M.

Bio-Algorithms and Med-Systems

2017

Vol. 13, no. 4

182--193

In this article, we describe the applicability of a signal processing method, specifically the modified S-transform (MST) method, on RNA sequences to identify periodicities between 2 and 11. MicroRNAs (miRNA) are associated with gene regulation and gene silencing and thus have wide applications in biological sciences. Also, the functionality of miRNA is highly associated with its secondary structures (stem, bulge and loop). Signal processing methods have been previously applied on genomic data to reveal the periodicities that determine a wide variety of biological functions, ranging from exon detection to microsatellite identification in DNA sequences. However, there has been less focus on RNA-based signal processing. Here, we show that the signal processing method can be successfully applied to miRNA sequences. We observed that these periodicities are highly correlated with the secondary structure of miRNA and such methods could possibly be used as indicators of secondary and tertiary structure formation.