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  1. 20 Acta of Bioengineering and Biomechanics
  2. 20 Engineering of Biomaterials
  3. 3 Czasopismo Techniczne. Mechanika
  4. 3 Inżynieria Biomateriałów
  5. 3 Technical Transactions. Mechanics
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  1. 3 Pamuła Elżbieta
  2. 2 Aksakal B.
  3. 2 Cholewa J.
  4. 2 Cichoń Ewelina
  5. 2 Czechowska Joanna
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  1. 3 2023
  2. 8 2021
  3. 3 2020
  4. 8 2019
  5. 2 2018
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1
Content available remote Chirurgiczna piła oscylacyjna obniżająca siły przy cięciu kości
Jemielniak Krzysztof
Mechanik
|
2023
|
R. 96, nr 5-6
10
PL
Przy przecinaniu kości chirurgicznymi piłami oscylacyjnymi często występują znaczne siły skrawania, które zmniejszają dokładność i skuteczność zabiegu. W artykule przedstawiono eksperymenty dotyczące cięcia świeżych kości bydła i symulowanych kości z użyciem pił o różnych kształtach zębów i geometrii ostrza.
2
Content available Optimization of the calcium carbonate particles manufacturing process by the precipitation method and biological evaluation with MG-63 cells
Pudełko-Prażuch Iwona, Wojtanek Karolina, Pamuła Elżbieta
Engineering of Biomaterials
|
2023
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vol. 26, no. 170
20--27
EN
As a natural mineral, calcium carbonate (CaCO3) is widely investigated for various medical applications. It is a biocompatible material characterized by high degradation rate and great osteoconductivity. Many researchers evaluate CaCO3 in the form of particles as a candidate for use in drug delivery systems. In this study we present an optimization of the process of producing CaCO3 particles by the precipitation method with the use of combinations of different time of ultrasound treatment and surfactant concentrations used. Depending on the synthesis conditions, various sizes of particles were fabricated. The particles were loaded with sodium alendronate (Aln, 5% or 10% by weight) with a relatively high encapsulation efficiency between 40 and 50%, depending on the amount of Aln added and the drug loading of approximately 9% for both cases. MG-63 osteoblast-like cells were contacted with 10% wt./vol extracts of fabricated particles to assess their cytotoxicity. None of the extracts investigated was found to be cytotoxic. Furthermore, an in vitro study in direct contact of MG-63 cells with particles suspended in culture medium was performed. The results showed that the fabricated particles are cytocompatible with osteoblast-like MG-63 cells. However, the higher the concentration of the particle suspension and the greater the amount of alendronate present in the solution, the lower the metabolic activity of the cells was measured. The presented method of CaCO3 particles manufacturing is simple, cost-effective, and allows one to fabricate particles of the required size and shape that are cytocompatible with MG-63 cells in defined concentrations of particle suspensions.
3
Content available Mesenchymal stem cells proliferation and osteogenic differentiation on polymeric scaffolds and microspheres for bone tissue engineering
Walczak Kamila, Krok-Borkowicz Małgorzata, Pamuła Elżbieta
Engineering of Biomaterials
|
2023
|
vol. 26, no. 170
14--19
EN
In this study, we aimed to compare how the microstructure and architecture of polymer supports influence adhesion, growth and differentiation of human mesenchymal stem cells (hMSC) in the context of bone tissue engineering. We manufactured poly(L-lactide-co-glycolide) (PLGA) three-dimensional supports in the form of microspheres by emulsification and porous scaffolds by solvent casting/ porogen leaching. HMSC were seeded on both materials and on control tissue culture polystyrene (TCPS, bottom of the wells) and cultured in basal or osteogenic medium for 1, 3, 7 and 14 days. HMSC proliferation and osteogenic differentiation were studied using lactate dehydrogenase (LDH) and alkaline phosphatase (ALP) assays, respectively. Furthermore, cell morphology and viability were analyzed after live/dead fluorescence staining. The results show that the optimized emulsification conditions allowed the production of PLGA microspheres with a median size of 95 µm. The PLGA scaffolds had a porosity of 82.1% ± 4.2% and a pore size of 360 µm ± 74 µm. HMSC cultured on control TCPS in osteogenic medium were more spread and polygonal than those in basal medium. They were characterized with a lower proliferation rate, as shown by the LDH results, but higher ALP activity. This suggests that hMSC osteogenic differentiation was achieved. The same tendency was observed for cells cultured on microspheres and scaffolds. Cell proliferation was more efficient on both materials and control in growth medium as compared to differentiation medium. The amount of ALP, i.e. a marker of osteogenic differentiation, was elevated, as expected, in differentiation medium. However, on day 14 cells cultured on the scaffolds in basal medium exhibited the same osteogenic potential as those cultured in differentiation medium. In general, both microspheres and scaffolds promoted hMSC adhesion, proliferation, and osteogenic differentiation and may be used for bone tissue engineering.
4
Content available The encapsulation of antibacterial drugs in polymer nanoparticles and their use in drug delivery systems on ZrO2 scaffold with bioactive coating
Pudełko Iwona, Desante Gaëlle, Pamuła Elżbieta, Schickle Karolina, Krok-Borkowicz Małgorzata
Engineering of Biomaterials
|
2021
|
Vol. 24, no. 161
21--27
EN
Bone infections are a challenging problem as they may cause a permanent patient disability and even death. Additionally, their relapse rate is relatively high. The implantation of a local drug delivery system can be an effective way to fight bone infections. In this study, we present the process of surface bioactivation and immobilization of nanoparticles loaded with drugs. Our aim was to improve osseointegration of the ZrO2 surface by coating it with a bioactive layer containing poly(L-lactide-co-glycolide)(PLGA) nanoparticles (NPs) loaded with antibacterial drugs (gentamicin and bacitracin) using a biomimetic precipitation method. The ZrO2 substrates were prepared via pressing and sintering. The CaP-coating was obtained by immersing the substrates in ten-times concentrated simulated body fluid (10×SBF). NPs were prepared by the double emulsion method and the drug loading in NPs was assessed. Thus obtained NPs were applied on bioactivated ceramic substrates by the drop-casting method or by introducing them in the 10×SBF solution during the bioactivation process. The NPs were visualized using scanning electron microscopy (SEM). The NPs size and the Zeta potential were measured using dynamic light scattering (DLS) method. The microstructure of the coating and the efficiency of the NPs incorporation were tested by SEM. In this study, we proved the presented process to be an effective way to obtain biomaterials that could be used as drug delivery systems to treat bone infections in the future.
5
Content available Preparation and preliminary in vivo studies of resorbable polymer modified with allogenic bone chips for guided bone regeneration and orthopedic implants
Szaraniec Barbara, Szponder Tomasz, Gryń Karol, Ambroziak Maciej, Gut Grzegorz, Koperski Łukasz, Chłopek Jan
Engineering of Biomaterials
|
2021
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Vol. 24, no. 162
13--19
EN
Composites made of resorbable polylactide modified with bone powder are part of the current search for implantable materials endowed with advantageous biomechanical functions, which make them suitable for orthopedics and traumatology applications. The bone additive containing active bone morphogenetic proteins (BMPs) and calcium phosphates introduced into the polymer matrix is to grant the implant with a biological activity. Subsequently, the resorbable matrix should get replaced with bone tissue. In order to avoid losing the osteoinductive properties of the designed material, it should be processed at low temperatures via physicochemical methods. This paper is devoted to the preparation and optimization of the composite production method suitable for biodegradable polymers and morphogenetic proteins along with the assessment of biocompatibility and biological properties of obtained materials. The tape-casting method was successfully applied. Resorbable polymer (medical poly-L-lactide, Purasorb PL38 by Purac) with 15 wt% of human bone powder (from tissue bank) were used to fabricate PLA-CP/BMPs composite implants. They were tested in in vivo studies that were performed in rabbit bone tissues. The results show a high biocompatibility of the material and good osteointegration with bone tissue.
6
Content available Multifunctional biomaterials based on nanostructured anodic titanium dioxide
Jarosz Magdalena, Sulka Grzegorz D.
Engineering of Biomaterials
|
2021
|
Vol. 24, no. 163
35
7
Content available Foamed calcium phosphate cements and their behaviour during incubation in distilled water
Cichoń Ewelina, Prajsnar Justyna, Guzik Maciej, Czechowska Joanna, Skibiński Szymon, Pańtak Piotr, Ślósarczyk Anna, Zima Aneta
Engineering of Biomaterials
|
2021
|
Vol. 24, no. 163
27
8
Content available Design of initial fixation in bone of customized innovative hip resurfacing endoprosthesis based on validated numerical model of the biomimetic multi-spiked connecting scaffold embedding in bone and data from the human osteoarthritic femoral heads μCT assessment
Uklejewski Ryszard, Patalas Adam, Winiecki Mariusz, Rogala Piotr
Engineering of Biomaterials
|
2021
|
Vol. 24, no. 163
21
9
Content available Deposition of iron on carbon nonwovens by magnetron sputtering
Giełdowska Małgorzata, Tuz Damian, Król Paulina, Boguń Maciej
Engineering of Biomaterials
|
2021
|
Vol. 24, no. 163
69
10
Content available Biological properties of nanosilver-loaded PMMA bone cement doped with bioactive glass
Wekwejt Marcin, Chen Si, Łukowicz Krzysztof, Pałubicka Anna, Osyczka Maria, Michno Anna, Michálek Martin, Zieliński Andrzej
Engineering of Biomaterials
|
2021
|
Vol. 24, no. 163
83
11
Content available Biodegradable tricalcium phosphate/poly(3-hydroxybutyrate) scaffolds for bone tissue regeneration
Skibiński Szymon, Pańtak Piotr, Cichoń Ewelina, Guzik Maciej, Czechowska Joanna, Ślósarczyk Anna, Zima Aneta
Engineering of Biomaterials
|
2021
|
Vol. 24, no. 163
74
12
Content available Stem cells response on photo-crosslinked heparin – bone morphogenetic proteins (BMP-2/-7) hybrid systems
Wytrwal-Sarna Magdalena, Pomorska Agata, Sekula-Stryjewska Małgorzata, Zuba-Surma Ewa, Szczubiałka Krzysztof
Engineering of Biomaterials
|
2020
|
Vol. 23, no. 158 spec. iss.
16
13
Content available Improving antibacterial activity of bone cement doped with nanosilver
Wekwejt Marcin, Michalska-Sionkowska Marta, Nadolska Małgorzata, Pałubicka Anna, Zieliński Andrzej
Engineering of Biomaterials
|
2020
|
Vol. 23, no. 158 spec. iss.
48
14
Content available Bone morphogenetic protein-2 adsorption on photoactive polymeric substrates
Wytrwal-Sarna Magdalena, Pomorska Agata, Sekula-Stryjewska Małgorzata, Gajos Katarzyna, Awsiuk Kamil, Sarna Michał, Zuba-Surma Ewa, Szczubiałka Krzysztof
Engineering of Biomaterials
|
2020
|
Vol. 23, no. 158 spec. iss.
15
15
Content available Titania nanotubes as scaffolds with optimal nanotopography for adipose-derived stem cells
Radtke Aleksandra, Ehlert Michalina, Piszczek Piotr, Roszek Katarzyna, Jędrzejewski Tomasz
Engineering of Biomaterials
|
2019
|
Vol. 22, no. 153 spec. iss.
49
16
Content available The influence of phase change material (PCM) on selected properties of polyurethane/magnetite systems
Lach Aleksandra, Pielichowska Kinga
Engineering of Biomaterials
|
2019
|
Vol. 22, no. 153 spec. iss.
95
17
Content available The factors governing hydrolytic degradation of polyesters-based scaffolds in bone tissue engineering
Walejewska Ewa, Idaszak Joanna, Heljak Marcin, Chlanda Adrian, Choińska Emilia, Święszkowski Wojciech
Engineering of Biomaterials
|
2019
|
Vol. 22, no. 153 spec. iss.
86
18
Content available Short calcium phosphate whiskers as reinforcement of polymer composites for bone tissue regeneration
Biernat Monika, Jaegermann Zbigniew, Oziębło Artur
Engineering of Biomaterials
|
2019
|
Vol. 22, no. 153 spec. iss.
38
19
Content available Modification of hydroxyapatite by anionic substitution
Borkowski Leszek, Przekora Agata, Belcarz Anna, Józefaciuk Grzegorz, Ginalska Grażyna
Engineering of Biomaterials
|
2019
|
Vol. 22, no. 153 spec. iss.
29
20
Content available Impact of ZrO2 additive on properties of PMMA-based bone cement
Laska-Leśniewicz Anna, Gaudyńska Marta, Gawlik Patrycja, Sobczyk-Guzenda Anna
Engineering of Biomaterials
|
2019
|
Vol. 22, no. 153 spec. iss.
69
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