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1

Adipose derived stem cells and ginkgo biloba extract-loaded PCL/gelatin nanofibrous scaffolds for peripheral nerve injury repair: The impact of physical activity

Gong Hua, Chen Zhengtian

Acta of Bioengineering and Biomechanics

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2023

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Vol. 25, no. 4

EN

Peripheral nerve damages take place as a result of trauma, compression, or disease, resulting in sensory loss, impaired motor function, and subsequent challenges. In the current study, ginkgo biloba extract was loaded into PCL/gelatin scaffolds through electrospinning method. The scaffolds were characterized in vitro using various studies. The prepared nanofibrous scaffolds were rolled up to make neural guidance channels. Then, the conduits were seeded with adipose derived stem cells and transplanted into a rat model of sciatic nerve injury. The scaffolds were not toxic and had optimal tensile and suturability. The animals treated with the conduits that delivered adipose derived stem cells and ginkgo biloba extract and received the treadmill exercise had significantly higher motor and sensory functions recovery. In addition, histopathological examinations showed beneficial role of the exercise plan on the nervous system repair.

2

Evaluation of design and insertion analysis of a conical shaped polymeric based microneedle for transdermal drug delivery applications

Gera Aswani Kumar, Burra Rajesh Kumar

Acta Innovations

|

2023

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no. 46

54--65

EN

Transportation of drug through parental routes are conventionally followed through hypodermic injection methods, where hypodermic injections are administered into the human skin for drug release. However, there are some issues observed when these hypodermic needles are being used, there are instances where the needle is being inserted leaves some needle fractures in the skin. To cater to the issue scientific researchers are voraciously working on designing and developing polymeric type of microneedle structures for various medical diagnostic applications for glucose monitoring, drug delivery, and other applications. This article presents the structural design of a conicalshaped polymeric microneedle and the insertion force while being pierced into the skin. Simulations at different insertion angles on microneedle are analyzed by arriving with total needle displacements in the process of insertion. The von mises stress is also analyzed with applied force at different insertion angles resulted in incremental change in stress exerted by the microneedle. The resultant stress is below the yield stress which makes the microneedle pierce into the skin without breakage.

3

Układy hybrydowe na bazie krzemionki i haloizytu do zastosowań środowiskowych i biomedycznych

Kurczewska Joanna

Wiadomości Chemiczne

|

2022

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[Z] 76, 7-8

529--550

EN

Silica and halloysite are inorganic materials of great importance in various areas of industry. Inorganic-organic hybrid systems obtained on their basis allow for the expansion of potential applications to new directions and improve their properties in the context of possible applications. Silica is characterized by good selectivity and mechanical stability. It consists of siloxane and silanol functional groups that can be functionalized with different organic units. Halloysite is an aluminosilicate clay mineral with silica and alumina sheets. It is often characterized by tubular structure, and its internal and external surfaces can be easily functionalized. Two large areas of application for hybrid materials based on silica and halloysite are environmental protection and medicine. Herein, the exemplary materials dedicated to the adsorption of impurities and drug delivery systems are presented.

4

Ostatnie doniesienia na temat nanocząstek złota jako biomateriału w stomatologii i medycynie

Sadlik Julia, Szechyńska Joanna, Grzywacz Oliwia, Słota Dagmara, Piętak Karina, Florkiewicz Wioletta

Inżynieria Materiałowa

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2022

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Vol. 43, nr 3

14--19

PL

W ostatnich latach nanotechnologia znacząco rozwinęła się jako dziedzina nauki badająca obiekty o rozmiarach nanometrycznych. Każdego roku pojawia się coraz więcej doniesień i kolejnych koncepcji wykorzystujących różne rodzaje nanomateriałów, głównie w dziedzinie biomedycyny. W tym kontekście szczególnie interesujące są nanocząstki złota cieszące się rosnącym zainteresowaniem naukowców przede wszystkim ze względu na swoje unikalne właściwości optyczne i chemiczne. W przeglądzie skupiono się na ostatnich doniesieniach dotyczących wykorzystania nanocząstek złota, na omówieniu metod ich syntezy oraz właściwościach.

EN

In recent years, nanotechnology has significantly developed as a scientific field that studies nanometer-sized objects. Every year an increasing number of reports and new concepts using different types of nanomaterials appear, mainly in the biomedical field. In this context, gold nanoparticles are of particular interest; they are of growing interest to researchers mostly due to their unique optical as well as chemical properties. The following review focuses on recent reports on the use of gold nanoparticles, furthermore discussing the synthesis methods and their properties.

5

Hydrogel microspheres containing dextran-based nanoparticles as novel anticancer drug delivery system

Kulikowska-Darłak Aleksandra, Stefanek Agata, Wasiak-Wojasińska Iga, Wiechecka-Ożdżyńska Paulina, Ciach Tomasz

Chemical and Process Engineering

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2022

|

Vol. 43, nr 3

405-–417

EN

Developing an effective and safe cancer therapy could significantly reduce the number of deaths and improve the quality of life of treated patients. Nowadays medicine has developed a wide range of anticancer chemotherapeutics but at the same time there is a lack of effective drug delivery methods. Therefore, the development of the targeted drug delivery system which will selectively release drug into the cancer cells is a key challenge of modern medicine. The main aim of the presented research was to investigate the targeting effect of a drug delivery system based on the controlled release of dextran nanoparticles containing the anticancer drug – doxorubicin from the alginate microspheres coated with chitosan multilayers. During the research the physicochemical properties of the alginate microspheres and its stability in the physiological environment were investigated. Moreover, the kinetics of the nanoparticles with doxorubicin release from the alginate microspheres covered with chitosan multilayers was characterized, depending on the thickness of the chitosan layer. Further, the cytotoxicity study of the alginate microspheres covered with chitosan multilayer and containing nanoparticles was performed to determine the therapeutic effect of the released nanoparticles with doxorubicin on the HeLa cells during the in vitro cell culture.

6

Wybrane zagadnienia fizykochemii koloidów w procesach inhalacyjnego dostarczania leków do płuc

Sosnowski Tomasz R., Dobrowolska Katarzyna

Wiadomości Chemiczne

|

2021

|

[Z] 75, 9-10

1376--1393

EN

The paper highlights selected problems of physical chemistry and dynamics of colloidal systems indispensable for the understanding and optimization of drug delivery by inhalation. Besides describing the fundamental aspects of aerosol flow and deposition in the respiratory system, some problems related to particle or droplet generation in the inhalers are discussed. In particular, the influence of liquid properties on aerosol formation in different nebulizers is demonstrated as a critical factor in successful aerosol therapy. The paper also addresses interactions between inhaled drug particles and bronchial mucus or the pulmonary surfactant, indicating another broad field of colloid and interface science application in medicine.

7

Nanocząstki magnetyczne w diagnostyce i leczeniu chorób nowotworowych

Piech Radosław, Skrzypiec Maksymilian, Drabczyk Anna

Inżynieria Materiałowa

|

2021

|

Vol. 42, nr 6

15--23

PL

W ostatnich latach intensywnie bada się nanocząstki magnetyczne (MNPs) pod względem użycia ich w medycynie, głównie w walce z chorobami nowotworowymi. Przy użyciu nanocząstek magnetycznych możliwe jest celowe, nieinwazyjne dostarczenie leku w miejsce kumulacji komórek rakowych za pomocą m.in. pola magnetycznego, co faworyzuje je w stosunku do klasycznych cytostatyków, które uszkadzają również zdrowe komórki i oddziałują na cały organizm. Nanocząstki magnetyczne mogą służyć również do wykrycia i zdiagnozowania chorób nowotworowych, jak również określania postępów terapii antynowotworowej. Różnorodność zastosowania nanocząstek magnetycznych sprawia, że są one postrzegane jako innowacyjny i przełomowy środek do zwalczania chorób nowotworowych. W artykule zebrano informacje na temat najpopularniejszych metod wytwarzania nanocząstek magnetycznych i ich wykorzystania w medycynie oraz poruszono kwestię biokompatybilności i toksyczności tychże struktur.

EN

Magnetic nanoparticles have attracted attention because of their properties that make it possible to use them to treat cancer through targeted therapy. By using a magnetic field to target nanoparticles containing drugs, it is possible to reach cancer cells directly and fight them in their place of growth without affecting healthy cells or the body as a whole. Magnetic nanoparticles can be used in diagnostics to detect and diagnose cancer as well as to determine the progress of anti-cancer therapy. In this paper, we mentioned the biocompatibility and toxicity of magnetic nanoparticles because their use also carries the risk of health damage which is a necessity for further research on this topic.

8

Porous poly(lactic acid) based fibres as drug carriers in active dressings

Dzierzkowska Ewa, Ścisłowska-Czarnecka Anna, Matwally Sara, Romaniszyn Dorota, Chadzińska Magdalena, Stodolak-Zych Ewa

Acta of Bioengineering and Biomechanics

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2020

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Vol. 22, no. 2

185--197

EN

Purpose: The polymeric porous surface of fibres (PLA) may influence the kinetics of release of biologically active compounds (gentamicin, G and ethacridine lactate, R) affecting development of a bacterial biofilm. Methods: The porous fibres with different morphology were manufactured by the electrospinning method from ternary systems composed of PLA and selected solvents. Fibres morphology was examined using a scanning electron microscopy (SEM), their structure was analyzed by FT-IR ATR spectroscopy and differential scanning calorimetry (DSC). Changes in the drug release profile were measured using ICP/UV-Vis methods and the resulting bactericidal or bacteriostatic properties were tested by two-layer disk diffusion test in relation to various drug incorporation methods. Results: The porous fibres can be applied to produce drug-bearing membranes. The spectroscopic studies confirmed incorporation of gentamicin into the fibres and the presence of ethacridine lactate on their surface. Bimodal fibres distribution (P3) promoted faster release of gentamicin and ethacridine lactate from P3G and P3R materials. The electrospinning process coupled with the vapor induced phase separation influenced the glass transition temperature of the porous polymer fibres. The pre/post-electrospinning modification influenced the glass transition, maximum temperature of cold crystallization and melting point of the porous membrane, compared to the neat polymer. The polylactide fibres with gentamicin showed strong bactericidal effect on Gram-positive bacteria, while fibres with ethacridine lactate were bacteriostatic. Conclusions: The obtained fibres with complex surface morphology can be used as a membrane in active dressings as they make it possible to control the release profile of the active compounds.

9

Rheology of drugs for topical and transdermal delivery

Walicka A., Falicki J., Iwanowska-Chomiak B.

International Journal of Applied Mechanics and Engineering

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2019

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Vol. 24, no. 1

179--198

EN

Skin drug delivery systems are a constant source of interest because of the benefits that they offer to overcome many drawbacks associated with other modes of drug delivery (i.e. oral, intravenous, etc.). Because of the impermeable nature of the skin, designing a suitable drug delivery vehicle that penetrates the skin barrier is challenging. Skin drug delivery can be subdivided into topical and transdermal (Fig.1). In a topical administration the drug is intended to act at skin level, this is indicated for the treatment of skin diseases. The aim of transdermal administration is getting a systemic release and in this case the skin represents a barrier not a target. The availability of drugs or other active substances through the skin depends basically on two consecutive steps: the release of these drugs or substances from vehicle or carrier and their subsequent permeation through the skin. Hence, studies on the specific properties of vehicles or carriers, such as their rheological behaviours, are of great interest in the field of pharmaceutical products. The objective of the present study is to systematically characterize a nonlinear rheological behaviour and flow properties of drugs and drug carriers into topical and transdermal administration. To this aim, one- and threedimensional rheological models are presented, which may be used to describe drug release through the skin and through the extracellular and interstitial matrix structures. Finally, the rheological measurements of some commercial creams and ointments were made.

10

Drug-loaded mesoporous silica/calcium phosphate composites for bone regeneration

Szewczyk Adrian, Skwira Adrianna, Prokopowicz Magdalena

Engineering of Biomaterials

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2019

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Vol. 22, no. 150

16--21

EN

In this work, we obtained a mesoporous silica-calcium phosphate composite (MSi-CaP) in the form of spherical granules (pellets) loaded with cefazolin as a model antibiotic. First, the MSi-CaP composite was manufactured in the powder form via the sol-gel method using a soft template. The cefazolin was loaded into the MSi-CaP using the immersion method. The pellets were composed of MSi-CaP powders (both placebo and cefazolin-loaded) and excipients, such as microcrystalline cellulose and ethyl cellulose. The pellets were obtained in the laboratory scale using the wet-granulation, extrusion and spheronization method. The pellets proved satisfactory mechanical properties which allowed for further investigations (the drug release studies and the mineralization potential assay) without a risk of pellets cracking. The complete drug release from the pellets was observed after 12 h. The burst release of cefazolin from the pellets was reduced by 3 when compared to the burst release of cefazolin-loaded MSi-CaP powders (90 and 30% after 15 min of release studies, respectively). The pellets showed the mineralization potential in vitro, confirmed by the SEM-EDX and FTIR methods. After 60 days of the mineralization potential assay in the simulated body fluid, the examinations revealed that the whole surface of pellets was covered with the carbonated hydroxyapatite in accordance with the desired morphology.

11

Fractal model of transdermal drug delivery

Walicka A., Iwanowska-Chomiak B.

International Journal of Applied Mechanics and Engineering

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2018

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Vol. 23, no. 4

989--1004

EN

Skin, separating the vital organs of a human body, is a desirable route for drug delivery. However, the intact skin is normally permeable only for drug molecules with a low molecular weight. The stratum corneum (SC), being the outermost layer of the skin and the epidermis being the second – more permeable – layer of the skin, play an essential function in transdermal drug delivery. Physical and chemical methods of skin poration are used to enhance transdermal drug delivery. Each poration leads to an irregular system of pores which are connected with a system of micro-capillaries passing through the epidermis. Both the systems by their irregularity form a fractal porous matrix. Drugs administrated by this matrix can be either suspensions and solutions or creams and gels, therefore they have to be modelled as non-Newtonian fluids. To analyse the fluid flow through the porous matrix the model of the epidermis is assumed as gobbet-andmortar with the tortuous mortar of variable thickness and after transition from the mortar to the tube one considered classical and fractal capillary flows of selected non-Newtonian fluids. Fractal expressions for the flow rate, velocity and permeability of fluids flow in a porous matrix are derived based on the fractal properties of the epidermis and capillary model. Each parameter in the proposed expressions does not contain any empirical constant and has a clear physical meaning and the proposed fractal models relate the flow properties of considered fluids with the structural parameters of the epidermis as a porous medium. The presented analytical expressions will help understand some of the physical principles of transdermal drug delivery.

12

Drug diffusion transport through human skin

Walicka A., Iwanowska-Chomiak B.

International Journal of Applied Mechanics and Engineering

|

2018

|

Vol. 23, no. 4

977--988

EN

The stratum corneum (SC) forms the outermost layer of the human skin and is essentially a multilamellar lipid milieu punctuated by protein-filled corneocytes that augment membrane integrity and significantly increase membrane tortuosity. The lipophilic character of the SC, coupled with its intrinsic tortuosity, ensure that it almost always provides the principal barrier to the entry of drug molecules into the organism. Drugs can be administered either as suspensions or as solutions and the formulation can range in complexity from a gel or and ointment to a multilayer transdermal path. In this paper, we discuss theoretical principles used to describe transdermal release and we show that relatively simple membrane transport models based on the appropriate solution to the Fick’s second law of diffusion can be used to explain drug release kinetics into such a complex biological membrane as the human skin. To apply the Fick’s law we introduced into our considerations a brick-and-mortar model with two factors of tortuosity. Assuming that the mortar thickness is variable we also introduced the hindrance factor allowing us to model this variability. Having the modified Fick’s equation we presented its general solution and two special cases of this solution frequently applicable in permeation experiments. It seems that the solutions presented herein better approximate the real conditions of drug delivery then these well known.

13

Wykorzystanie grafenu w medycynie : studium literaturowe

Bojko Ł., Ryniewicz A. M.

Problemy Nauk Stosowanych

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2015

|

T. 3

147--156

PL

Wstęp i cele: Wyizolowanie warstwy grafenu przez Andre Geim i Kostya Novoselov nastąpiło w 2004 roku. Ze względu na specyficzne właściwości elektryczne, optyczne, chemiczne i mechaniczne grafen znalazł zastosowanie w wielu dziedzinach, w tym w medycynie. Opracowanie poświęcone jest podsumowaniu najnowszych osiągnięć wykorzystania grafenu w procesie dostarczania leków, wykrywania i obrazowania struktur tkankowych, komórkowych i genowych, w tym terapii nowotworów oraz jako materiał w inżynierii tkankowej. Materiał i metody: Materiałem jest literatura dotycząca zagadnień zastosowania grafenu w medycynie. Zastosowano metodę analizy merytorycznej. Wyniki: Analiza literatury pokazuje, że przeszkodami dla biomedycznych zastosowań nanomateriałów na bazie grafenu jest brak biodegradacji i możliwość wystąpienia toksyczności długoterminowej, a obecne badania nie dostarczają pełnej wiedzy w zakresie oddziaływania in vivo nanomateriałów na bazie grafenu, o różnej strukturze, wielkości i właściwości powierzchni. Wniosek: Efektywność kierowania markerów do guzów nowotworowych jest jednym z kluczowych wyzwań biomedycznych dotyczących nie tylko materiałów na bazie grafenu, ale także większości innych nanomateriałów.

EN

Introduction and aims: The isolation of graphene layers by Andre Geim and Kostya Novoselov was in 2004. Due to the specific properties of the electrical, optical, chemical and mechanical properties, graphene has been applied in many fields, including medicine. Study is devoted to the summary of the latest achievements in the use of graphene to drug delivery, sensing and imaging tissue, cellular, and gene structures, including cancer therapy and as a material for tissue engineering. Material and methods: The material is literature on the issues of application of graphene in medicine. The method of theoretical analysis. Results: Analysis of the literature shows that obstacles to biomedical applications of nanomaterials based on graphene is the lack of biodegradability and the possibility of long-term toxicity and current research does not provide the full knowledge of the interactions in vivo graphene-based nanomaterials, with a different structure, size and surface properties. Conclusion: Efficiency of targeting cancerous tumors markers is one of the key challenges regarding not only the biomedical materials based on graphene, but also most other nanomaterials.

14

Magnetic core-shell structures as potential carriers in drug delivery system

Łuszczyk K.

Interdisciplinary Journal of Engineering Sciences

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2014

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Vol. 2, no. 1

1--4

EN

Magnetic core-shell structures have a high potential for promising application in biomedicine as drug carriers. In this paper, magnetic core-shell structure obtained by the sol-gel method was presented. In order to provide the protective coating of magnetic MnFe2O4 nanoparticles, amorphous silica was used. It has been shown that magnetic core was successfully encapsulated in SiO2 matrix and that the received core-shell material had magnetic properties.

15

Reologia i mikroroboty

Fuksa A. K.

Logistyka

|

2013

|

nr 4

PL

W artykule przedstawiono zagadnienia związane z możliwością zastosowania mikrorobotów w biomedycynie a także wyzwania w modelowaniu mikrorobotów w biopłynach nienewtonowskich, takich jak ciało szkliste oka. Poruszono, między innymi, kwestię wykorzystania mikrorobotów w medycynie nieinwazyjnej, problematykę związaną z istniejącymi metodami leczenia chorób oczu, a także zagadnienia związane z modelowaniem reologicznym biopłynów.

EN

Microrobots are currently investigated for their potential use in biomedical applications. The vitreous humour of the eye represents a location where microrobots could potentially perform therapeutic or diagnostic tasks. This paper aims at developing general strategies for the modeling of the vitreous humour in view of the potential use of microdevices in non-Newtonian environments. The suitability of biomedical applications of microrobotics as well as existing strategies and limitations of existing ocular drug-delivery methods are examined. Finally, elements of non-Newtonian fluids mechanics are presented along with a discussion on different rheological models.

16

Drug delivery system based on polymer nanofibers

Nakielski P., Kowalczyk T., Kowalewski T.

IPPT Reports on Fundamental Technological Research

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2013

|

nr 4

19--24

EN

This work presents our attempts to characterize release of two model drugs from electrospun polymer nanofibers. Such drug delivery system offers great potential for applications in medicine especially as neurosurgery protective membranes. Proper delivery of drugs requires precise control of the drug diffusion process during the release for days or even weeks. Lipophilic model drug Rhodamine B and hydrophilic Bovine Serum Albumin conjugated with Fluoresceine (BSA-FITC) were embedded in electrospun poly(L-lactide-co-e-caprolactone) (PLC) nanofibers. Release of Rhodamine B showed saturation in cumulative release profile at 60% and 86% for 1.5% and 3% wt. initial drug content, respectively. Nanofibers electrospun from emulsion released almost entire drug encapsulated in water vesicles inside the nanofibers. Possible location of vesicles close to the surface of the nanofibers exposed them for surrounding fluid and caused leaching of the drug. In this case encapsulation of drug in emulsion prevented the initial burst release. Dependence of a drug release and composition of nanofiber is essential for production of drug delivery systems. Mathematical model constructed with this data allows to avoid tedious experimental work. This research was supported by Ministry of Science and Higher Education, National Centre for Research and Development Project grant no. R13008110. The first author has been supported with a scholarship from the European Social Fund, Human Capital Operational Programme.

17

Harnessing biopolyesters in the design of functional materials for biomedical applications

Renard E., Babinot J., Lemechko P., Ramier J., Vergnol G., Versace D. L., Grande D., Langlois V.

Engineering of Biomaterials

|

2012

|

Vol. 15, no. 113

19--22

EN

The present contribution illustrates the versatility of poly(3-hydroxyalkanoate)s (PHAs) in the design of a wide variety of biodegradable and/or biocompatible macromolecular architectures with controlled degradability. Firstly, functionalized PHAs were prepared from unsaturated PHAs. Pendant double bonds have been turned into carboxyl, hydroxyl, alkyne or epoxy groups. These reactive functions were used for further grafting hydrolyzable polylactide (PLA) or poly(ε-caprolactone) (PCL) as well as hydrophilic poly(ethylene glycol) (PEG). Additionally, block copolymers with a PLA, PCL or PEG segment have been prepared by ring-opening polymerization or "click" chemistry from a PHA oligomeric macroinitiator. Functional PHAs represent biodegradable aliphatic polyesters with many possibilities to tune physico-chemical characteristics, such as hydrophilicity and degradation rate, thus making the resulting materials suitable as devices for drug delivery or as scaffolds for tissue engineering. Herein, we address the recent trends in the synthesis of these polymeric materials and their applications in controlled drug delivery and tissue engineering.

18

Zastosowanie nanomateriałów w naukach medycznych

Moritz M., Geszke-Moritz M.

Chemik

|

2012

|

Vol. 66, nr 3

212-214

PL

Przedstawiono przebieg realizacji projektu "Bezpieczne chemikalia - projekt dla województwa śląskiego", współfinansowanego przez Unię Europejską ze środków Europejskiego Funduszu Społecznego w ramach Programu Operacyjnego Kapitał Ludzki, ze szczególnym uwzględnieniem form wsparcia udzielanego przedsiębiorcom regionu.

EN

Implementation of "Safe chemicals - a project for Silesia" project objectives, co-funded by the European Social Fund EU, with particular emphasis on forms of support to entrepreneurs of the region has been presented.

19

Delivery of nebulised drugs using endotracheal tube

Penconek A., Odziomek M., Niedzielska A., Moskal A.

Chemical and Process Engineering

|

2012

|

Vol. 33, nr 4

689--696

EN

The purpose of the studies was to estimate efficiency of delivering nebulised drugs into the lower respiratory tract through endotracheal tubes (ET tubes) which are commonly used in the treatment of uncooperative patients. Water solution of Disodium Cromoglycate (DSCG) was nebulised with a constant air flow (25 l/min). Experimental studies were done for eight ET tubes with varying sizes (internal diameter, length) and made of two different materials. Size distribution of aerosol leaving ET tubes was determined with the use of aerosol spectrometer. Fine Particle Fraction (FPF) and Mass Median Aerodynamic Diameter (MMAD) were calculated for the aerosol leaving each tube. Additionally, mass of the Disodium Cromoglycate deposited into each endotracheal tube was determined. ET tubes can significantly influence the parameters of delivered aerosol depending on their diameter. FPF of aerosol delivered in to the respiratory tract is lower if small endotracheal tubes are used. However, MMAD and FPF for large endotracheal tubes are almost identical with MMAD and FPF from nebuliser. The results indicate that a substantial fraction of large droplets is eliminated from the aerosol stream in long endotracheal tubes (270 mm). In this case the mass of drug delivered through ET tubes is reduced but the content of small droplets increases (high value of FPF).

20

Development of a drug delivery system using microcapsules with ultrasound

Masuda K.

Biocybernetics and Biomedical Engineering

|

2011

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Vol. 31, no. 2

23-32

EN

Micrometer-sized microcapsules collapse upon exposure to ultrasound. Use of this pheno-menon for a drug delivery system (DOS), not only for local delivery of medication but also for gene therapy, should be possible. However, enhancing of efficiency of medication is limited because the capsules in suspension diffuse in the human body after injection, since the motion of the capsules in blood flow cannot be controlled. To control behavior of the microcapsules, an acoustic radiation force was introduced. We detected local changes in the microcapsule density by producing of acoustic radiation force in an artificial blood vessel. Furthermore, we theoretically estimated the conditions required for an active path selection of the capsules at a bifurcation point in the artificial blood vessel. We observed the difference in the capsule density at both in the bifurcation point and in alternative paths downstream of the bifurcation point for the different acoustic radiation forces. We also confirmed that the microcapsules are trapped against flow with the condition when the acoustic radiation force is more than the fluid resistance of the capsules. The possibility of controlling of the capsule flow towards a specific point in a blood vessel was demonstrated.