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Selected optoelectronic sensors in medical applications

Bielecki Z., Stacewicz T., Wojtas J., Mikołajczyk J., Szabra D., Prokopiuk A.

Opto-Electronics Review

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2018

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Vol. 26, No. 2

122--133

EN

Optoelectronic technology plays an important role in medical diagnosis. In the paper a review of some optoelectronic sensors for invasive and non-invasive human health test is presented. The main attention is paid on their basic operation principle and medical usefulness. The paper presents also own research related to developing of tools for human breath analysis. Breath sample unit and three gaseous biomarkers analyzer employing laser absorption spectroscopy designed for clinical diagnostics were described. The analyzer is equipped with sensors for CO, CH₄ and NO detection. The sensors operate using multi-pass spectroscopy with wavelength modulation method (MUPASS-WMS) and cavity enhanced spectroscopy (CEAS).

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System of Optoelectronic Sensors for Breath Analysis

Mikołajczyk J., Wojtas J., Bielecki Z., Stacewicz T., Szabra D., Magryta P., Prokopiuk A., Tkacz A., Panek M.

Metrology and Measurement Systems

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2016

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Vol. 23, nr 3

481--489

EN

The paper describes an integrated laser absorption system as a potential tool for breath analysis for clinical diagnostics, online therapy monitoring and metabolic disorder control. The sensors operate basing on cavity enhanced spectroscopy and multi-pass spectroscopy supported by wavelength modulation spectroscopy. The aspects concerning selection of operational spectral range and minimization of interference are also discussed. Tests results of the constructed devices collected with reference samples of biomarkers are also presented. The obtained data provide an opportunity to analyse applicability of optoelectronic sensors in medical screening.

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Detection of Gaseous Compounds with Different Techniques

Mikołajczyk J., Bielecki Z., Stacewicz T., Smulko J., Wojtas J., Szabra D., Lentka Ł., Prokopiuk A., Magryta P.

Metrology and Measurement Systems

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2016

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Vol. 23, nr 2

205--224

EN

Sensing technology has been developed for detection of gases in some environmental, industrial, medical, and scientific applications. The main tasks of these works is to enhance performance of gas sensors taking into account their different applicability and scenarios of operation. This paper presents the descriptions, comparison and recent progress in some existing gas sensing technologies. Detailed introduction to optical sensing methods is presented. In a general way, other kinds of various sensors, such as catalytic, thermal conductivity, electrochemical, semiconductor and surface acoustic wave ones, are also presented. Furthermore, this paper focuses on performance of the optical method in detecting biomarkers in the exhaled air. There are discussed some examination results of the constructed devices. The devices operated on the basis of enhanced cavity and wavelength modulation spectroscopies. The experimental data used for analyzing applicability of these different sensing technologies in medical screening. Several suggestions related to future development are also discussed.

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Wybrane aspekty wykrywania chorób w układach analizy wydychanego powietrza

Mikołajczyk J., Wojtas J., Kustosz M., Magryta P., Stacewicz T., Bielecki Z.

Elektronika : konstrukcje, technologie, zastosowania

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2015

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Vol. 56, nr 8

7-9

PL

W artykule przedstawiono przykłady urządzeń do analizy wydychanego przez człowieka powietrza. Przeznaczone są one głównie do diagnostyki medycznej. W pracy przeanalizowano podstawowe właściwości komercyjnie dostępnych urządzeń zarówno przenośnych (np. elektrochemicznych, chemiluminescencyjnych), jak również bardziej złożonych np. chromatografów gazowych. Przedstawiono koncepcję systemu składającego się z czujników optoelektronicznych wykorzystujących spektroskopię strat we wnęce optycznej oraz spektroskopię z modulacją długości fali promieniowania z komórkami wieloprzejściowymi. W części eksperymentalnej przedyskutowano wstępne badania tych urządzeń w aspekcie zastosowań medycznych.

EN

The article presents some techniques for the human breath analysis in medical diagnostics. The properties of commercially available devices, both mobile (eg. electrochemical or chemiluminescent sensors), as well as more complex (gas chromatograph) are analyzed. The concept of the system consisting of two sensors based on cavity enhanced absorption spectroscopy and multipass wavelength modulation spectroscopy is described. Preliminary results of these sensors investigation in terms of medical applications are discussed in the experimental section.

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Optoelektroniczne sensory gazów

Bielecki Z., Wojtas J., Stacewicz T., Mikołajczyk J., Rutecka B., Mędrzycki R., Prokopiuk A.

Pomiary Automatyka Kontrola

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2013

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R. 59, nr 4

287--291

PL

W artykule przedstawiono prace dotyczące optoelektronicznych sensorów gazów oraz osiągnięcia własne w zakresie wykrywania tlenków azotu (NOx). W sensorach do wykrywania NOx zastosowano polskie lasery emitujące promieniowanie o długości fali 410 nm oraz nowoczesne kwantowe lasery kaskadowe na zakres podczerwieni. Opracowane sensory charakteryzują się czułością graniczną na poziomie ppb i mogą być zastosowane do monitoringu zanieczyszczeń atmosfery, wykrywania materiałów wybuchowych oraz w diagnostyce chorób.

EN

The paper presents an overview of a few optoelectronic technologies for gases detection. Two sensors of nitrogen oxides (NOx) are also described. In the sensors the cavity enhanced absorption spectroscopy was applied. It is characterized by a very good sensitivity and selectivity of the detection process. The main aspect of its operation bases on absorption of the light by specific compounds. The identification of the matter is determined by spectral matching of the two spectra: optical radiation and absorption lines of species of interest. In contrast to the remote detection methods, the measurements are made at the place of sampling. Polish laser diodes and modern quantum cascade lasers were used there. Laser emission wavelengths were located in the visible (410 nm) and infrared range. The detection limit of ppb level was achieved. Due to that, they can be successfully applied to monitoring of atmospheric pollution, explosives detection and in diseases diagnosis. The preliminary studies using the developed sensors showed that it was possible to detect explosives such as TNT, PETN, RDX, HMX at the level of ng. Additionally, there is also discussed application of sensors to analysis of the exhaled air. This will be particularly useful for: the early detection of a disease, the monitoring of the therapy, the monitoring of the greenhouse exogenous (bacterial emissions or toxins), or the analysis of metabolic gases.