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1
Content available Metal-organic frameworks for efficient drug adsorption and delivery
Hyjek Kornelia, Jodłowski Przemysław
Scientiae Radices
|
2023
|
Vol. 2, Iss. 2
115-189
EN
In recent years, the number of materials used as drug delivery systems (DDS) has increased dramatically. The widespread use of DDSs has improved both the safety and efficacy of therapy. The systems currently in use pose numerous drawbacks and require proper improvements. Although many modern materials are being developed, metal-organic frameworks (MOFs) deserve special attention. Thermal and chemical stability, high specific surface area, low toxicity, high biocompatibility, and great potential for modification are the main features enabling MOFs to be used as DDS. In this review, we describe MOFs, their structure, synthesis, and characterization, as well as drug loading, drug release kinetics, and bioassays. A critical approach is to outline the disadvantages as well as the limitations of MOFs and to identify areas that need to be studied more thoroughly. Nonetheless, the prospective nature of MOFs as DDS and potential adsorbents in overdose or poisoning is presented and highlighted.
2
Content available remote Zastosowania wybranych metali w przyrządach do monitorowania kultur in vitro
Zarzeczny Dawid
Przegląd Elektrotechniczny
|
2022
|
R. 98, nr 2
79--82
PL
W pracy opisany został problem związany z wysokimi nakładami koniecznymi do prowadzenia badań medyczno- -biologicznych. Zaproponowano możliwość zastosowania niestandardowych rozwiązań poprawiających efektywność kosztową prowadzenia eksperymentów in vitro metodą pomiaru impedancji elektrycznej. Opisano opracowane matryce z elektrodami wykonanych z różnych materiałów do pomiaru impedancji elektrycznej komórek in vitro. Pomiary przeprowadzono wykorzystując komórki mysich fibroblastów L929 z użyciem płytek z elektrodami z Cu, Ti, NiCr i Ni. Posłużyły one do oceny wpływu danego materiału na hodowlę komórek i próbę określenia możliwości ich zastosowania w eksperymentach medyczno-biologicznych.
EN
The paper describes the problem related to the high costs necessary to conduct medical and biological research. The possibility of using non-standard solutions improving the cost-effectiveness of conducting in vitro experiments using the electrical impedance measurement method was proposed. The developed matrices with electrodes made of various materials for the in vitro measurement of cell electrical impedance are described. Measurements were performed using mouse L929 fibroblast cells using plates with Cu, Ti, NiCr and Ni electrodes. They were used to assess the effect of a given material on cell culture and to attempt to determine the possibility of their use in medical and biological experiments.
3
Content available Biopolymers as renewable polymeric materials for sustainable development : an overview
Srivastava Abhinav, Srivastava Atul Kumar, Singh Ashutosh, Singh Priti, Verma Sangeeta, Vats Monika, Sagadevan Suresh
Polimery
|
2022
|
Vol. 67, nr 5
185--196
EN
Based on the review of 115 literature items, the article presents biopolymers as renewable polymer materials for sustainable development. The types of biopolymers and their applications are discussed, including biopolymers based on starch, cellulose, bacteria, soy and natural polyester. It also describes the issues of biocompatibility, the principles of sustainable chemistry and sustainable development, as well as market trends and future application directions.
PL
Na podstawie przeglądu 115 pozycji literaturowych w artykule przedstawiono biopolimery jako odnawialne materiały polimerowe dla zrównoważonego rozwoju. Omówiono rodzaje biopolimerów i ich zastosowanie, w tym biopolimery na bazie skrobi, celulozy, bakterii, soi i naturalnego poliestru. Opisano również zagadnienia dotyczące biokompatybilności, zasad zrównoważonej chemii i zrównoważonego rozwoju oraz trendy rynkowe i perspektywiczne kierunki zastosowań.
4
Content available Biomimetic scaffolds based on chitosan in bone regeneration. A review
Kołakowska Anna, Gadomska-Gajadhur Agnieszka, Ruśkowski Paweł
Chemical and Process Engineering
|
2022
|
Vol. 43, nr 3
305–-330
EN
Chitosan (CS) is a polysaccharide readily used in tissue engineering due to its properties: similarity to the glycosaminoglycans present in the body, biocompatibility, non-toxicity, antibacterial character and owing to the fact that its degradation that may occur under the influence of human enzymes generates non-toxic products. Applications in tissue engineering include using CS to produce artificial scaffolds for bone regeneration that provide an attachment site for cells during regeneration processes. Chitosan can be used to prepare scaffolds exclusively from this polysaccharide, composites or polyelectrolyte complexes. A popular solution for improving the surface properties and, as a result enhancing cell-biomaterial interactions, is to coat the scaffold with layers of chitosan. The article focuses on a polysaccharide of natural origin – chitosan (CS) and its application in scaffolds in tissue engineering. The last part of the review focuses on bone tissue and interactions between cells and chitosan after implantation of a scaffold and how chitosan’s structure affects bone cell adhesion and life processes.
5
Content available Corrosion Assessment of Nickel - Base - Dental Alloys in Ringer Biological Solution Studied by Electrochemical Techniques
Benea Lidia, Dragus L., Mocanu D.
Archives of Metallurgy and Materials
|
2022
|
Vol. 67, iss. 2
529--533
EN
The aim of this paper was to study the corrosion behavior of Nickel - Base - Dental Alloys in Ringer biological fluid. The Nickel base alloys are widely used for medical purposes, especially for prosthetic works in the field of dentistry. The applied electrochemical methods used for corrosion investigations are Open Circuit Potential, Linear Polarization during time of immersion in order to calculate the polarization resistance and corrosion rate. Potentiodynamic Polarization diagrams was performed to appreciate the passive domain. Ni-Cr Ugirex alloy show a better corrosion resistance in Ringer solution which will be reflected in a longer life of the dental structures made with this alloy as compared to the Ni-Cr Ducinox alloy, which will result in dental structures with a shorter lifespan. The electrochemical studies has shown that the alloy have a corrosion behavior similar to a passivating alloy, displaying an extensive passivity area due to formation of an oxide film.
6
Współczesne materiały wykorzystywane w inżynierii biomedycznej
Mordal Katarzyna, Maruszczyk Andrzej, Dobrakowski Karol
Przegląd Mechaniczny
|
2021
|
nr 2
28--35
PL
Artykuł jest pracą przeglądową i dotyczy nowoczesnych materiałów różnego rodzaju, które znalazły zastosowanie w biomedycynie, bioinżynierii oraz biomechanice. Poruszone zagadnienia obejmują wymagania stawiane biomateriałom oraz charakterystykę podstawowych pojęć z nimi związanych, tj. biozgodności, biotolerancji, biofunkcjonalności. W pracy przedstawiono materiały metaliczne oraz metody modyfikacji ich powierzchni w szczególności PVD i natryskiwanie plazmowe, w celu uzyskania odpowiednich własności związanych z biozgodnością i biokompatybilnością. Poza tym zostały również scharakteryzowane właściwości materiałów ceramicznych oraz możliwości ich zastosowania w różnych gałęziach bioinżynierii. Omówiono także przykłady tworzyw polimerowych oraz kompozytów, jakie współcześnie wykorzystuje się w biomechanice, stomatologii czy innych dziedzinach medycyny. Celem artykułu było przedstawienie kompleksowego przeglądu materiałów różnego rodzaju stosowanych w biomedycynie, bioinżynierii, biomechanice.
EN
This article is a review and has been devoted to all kinds of modern materials, which have been applied in biomedicine, bioengineering and biomechanics. The presented issues include requirements for biomaterials and characteristics of basic keywords related to them, i.e. biocompatibility, biotolerance, biofunctionality. The paper presents metallic materials and methods of surface modification, especially PVD and plasma spraying in order to achieving appropriate biocompatibility properties. Moreover, the properties of ceramic materials and their application in various branches of bioengineering have also been characterized. Also examples of polymeric materials and composites, that are used in biomechanics, dentistry or other fields of medicine are also have been discussed. Presenting a comprehensive overview of various types of biomaterials used in biomedicine, bioengineering, biomechanics have been the aim of the article.
7
Content available Bioresorbable polymeric materials – current state of knowledge
Wiśniewska Kamila, Rybak Zbigniew, Wątrobiński Marcin, Struszczyk Marcin H., Filipiak Jarosław, Żywicka Bogusława, Szymonowicz Maria
Polimery
|
2021
|
T. 66, nr 1
3--10
EN
Bioresorbable materials are used in medicine for fixing, correcting or stabilizing bones in various anatomical areas, and the market for such materials is growing rapidly worldwide. The use of polymers for their production is associated with the ability to control their properties. They are prepared from bioresorbable materials with variable surface, geometry, porosity, as well as mechanical and surface properties. They support bone healing and are suitable for tissue regeneration due to their biodegradability and biocompatibility. We believe that materials from biodegradable polymers will play an increasingly important role in future medicine.
PL
Materiały bioresorbowalne są szeroko stosowane wmedycynie do uzupełniania ubytków kości w różnych stanach chorobowych i powypadkowych, a także do nadbudowy iodbudowy kostnej oraz mocowania złamań. Rynek tego typu materiałów szybko się rozwija na całym świecie. Powszechność wykorzystania polimerów jest związana z możliwością kontrolowania ich właściwości. Zaletą materia-łów polimerowych jest możliwość zmiany powierzchni, geometrii, porowatości, właściwości mechanicz-nych ipowierzchniowych, atakże ich biodegradowalność ibiokompatybilność. Materiały z polimerów biodegradowalnych będą zapewne odgrywać coraz poważniejszą rolę w medycynie przyszłości.
8
Nanocząstki magnetyczne w diagnostyce i leczeniu chorób nowotworowych
Piech Radosław, Skrzypiec Maksymilian, Drabczyk Anna
Inżynieria Materiałowa
|
2021
|
Vol. 42, nr 6
15--23
PL
W ostatnich latach intensywnie bada się nanocząstki magnetyczne (MNPs) pod względem użycia ich w medycynie, głównie w walce z chorobami nowotworowymi. Przy użyciu nanocząstek magnetycznych możliwe jest celowe, nieinwazyjne dostarczenie leku w miejsce kumulacji komórek rakowych za pomocą m.in. pola magnetycznego, co faworyzuje je w stosunku do klasycznych cytostatyków, które uszkadzają również zdrowe komórki i oddziałują na cały organizm. Nanocząstki magnetyczne mogą służyć również do wykrycia i zdiagnozowania chorób nowotworowych, jak również określania postępów terapii antynowotworowej. Różnorodność zastosowania nanocząstek magnetycznych sprawia, że są one postrzegane jako innowacyjny i przełomowy środek do zwalczania chorób nowotworowych. W artykule zebrano informacje na temat najpopularniejszych metod wytwarzania nanocząstek magnetycznych i ich wykorzystania w medycynie oraz poruszono kwestię biokompatybilności i toksyczności tychże struktur.
EN
Magnetic nanoparticles have attracted attention because of their properties that make it possible to use them to treat cancer through targeted therapy. By using a magnetic field to target nanoparticles containing drugs, it is possible to reach cancer cells directly and fight them in their place of growth without affecting healthy cells or the body as a whole. Magnetic nanoparticles can be used in diagnostics to detect and diagnose cancer as well as to determine the progress of anti-cancer therapy. In this paper, we mentioned the biocompatibility and toxicity of magnetic nanoparticles because their use also carries the risk of health damage which is a necessity for further research on this topic.
9
Content available Tailoring hydrophilicity of poly(butylene succinate) (PBS) copolymers
Zarei Moein, El Fray Miroslawa
Engineering of Biomaterials
|
2021
|
Vol. 24, no. 163
64
10
Content available Biocidal properties of copper nanoparticles
Bayade Ghislaine, Wu Menq Rong, Massicotte Richard, Deryabin Dmitrij Gennad’evich, Yahia L’Hocine
Engineering of Biomaterials
|
2021
|
Vol. 24, no. 159
2--17
EN
Metal nanoparticles (NPs) with antibacterial properties represent a promising alternative approach to antibiotics, whose overuse has led to the appearance of drug-resistant bacteria. This article addresses particularly copper (Cu) nanoparticles since Cu is a structural constituent of many enzymes in living microorganisms. In addition, Cu has a better antibacterial effect and minimal cost compared to silver. The properties of Cu nanoparticles are described here: antibactericide, toxicity mechanisms, oxidation, and copper oxide biocompatibility for medical applications. Along with the advantages of Cu nanoparticles, the nanotoxicity still remains to take into consideration such as in targetting different bacteria strains, bacteria’s resistance, the effect of size, the effect of NP chemical composition, the effect of oxidation, and the corona phenomenon effect. The methodology of Cu nanoparticles synthesis, related to the biocidal effect, is illustrated by some limitations and some breakthrough such as chitosan stabilizer (CS), laser ablation, plasma induction, and flow-levitation method (FL). Although Cu nanoparticles are beneficial for bacterial elimination, these nanoparticles are graded harmful to the human body and the environment because of their toxic effects. Thus, it requires further improvement and further investigation to create super antibacterial Cu nanoparticles, to develop some interesting research work around this subject, and to reveal some promising medical findings.
11
Content available Bioactive hydrocolloid-type biomaterials for potential management of highly exuding wounds
Wojcik Michał, Kazimierczak Paulina, Vivcharenko Vladyslav, Przekora Agata
Engineering of Biomaterials
|
2021
|
Vol. 24, no. 163
49
12
Content available Adhesion, microstructure and surface topography of mesoporous, Cu-doped sol-gel glass/zein coatings electrophoretically deposited on Ti-13Nb-13Zr alloy substrates
Maciąg Filip, Cholewa-Kowalska Katarzyna, Dziadek Michał, Moskalewicz Tomasz
Engineering of Biomaterials
|
2021
|
Vol. 24, no. 163
51
13
Content available Struktura geometryczna powierzchni próbek ze stopu magnezu AZ31 po polerowaniu oraz modyfikacji biopolimerami wytwarzanymi metodą CVD
Gołąbczak Marcin, Maksim Przemysław, Skowron Marcin, Kyzioł Karol, Gołąbczak Andrzej, Działo Adam, Szkatulski Piotr
Obróbka Metalu
|
2020
|
nr 4
49--54
PL
W artykule przedstawiono wyniki badań dotyczące porównania parametrów struktury geometrycznej powierzchni (SGP) próbek ze stopu magnezu AZ31 po polerowaniu oraz po wytworzeniu na ich powierzchniach różnego typu biokompatybilnych powłok ochronnych. Zakres prezentowanych badań obejmował proces przygotowania próbek do ich cięcia metodą WEDM, polerowania krążkami ściernymi, chemicznego trawienia oraz modyfikację ich powierzchni poprzez wytworzenie biopolimerowych powłok ochronnych metodą chemicznego osadzania z fazy gazowej CVD.
EN
In this paper the results of investigations concerning the comparison of surface geometric structure parameters of samples made of magnesium alloy AZ31 were presented. The samples were polish and coated of various types of biocompatible protective coatings. The scope of presented studies included the process of sample preparation by WEDM cutting, abrasive disc polishing, chemical pickling and modification of their surface by producing biopolymer protective coating by chemical deposition from gas phase (CVD).
14
Content available Modification of carbon materials surfaces by plasma: effect of the introduced functional groups on biocompatibility and adhesion of microorganisms
Duch Joanna, Pajerski Wojciech, Gołda-Cępa Monika, Ochońska Dorota, Piskorz Witold, Brzychczy-Włoch Monika, Rysz Jakub, Kotarba Andrzej
Engineering of Biomaterials
|
2020
|
Vol. 23, no. 158 spec. iss.
42
15
Content available How to stimulate polymeric surfaces biocompatibility and hydroxyapatite formation: experiments supported by MD simulations
Gołda-Cępa Monika, Chytrosz Paulina, Riedlova Kamila, Kulig Waldemar, Ćwiklik Łukasz, Kotarba Andrzej
Engineering of Biomaterials
|
2020
|
Vol. 23, no. 158 spec. iss.
40
16
Content available Functionalization of polyurethane surfaces for improved biocompatibility
Chytrosz Paulina, Gołda-Cępa Monika, Kotarba Andrzej
Engineering of Biomaterials
|
2020
|
Vol. 23, no. 158 spec. iss.
37
17
Content available Study of selected physical, chemical and biological properties of selected materials intended for contact with human body
Mrówka Maciej, Machoczek Tomasz, Jureczko Paweł, Szymiczek Małgorzata, Skonieczna Magdalena, Marcoll Łukasz
Polish Journal of Chemical Technology
|
2019
|
Vol. 21, nr 1
1--8
EN
The purpose of the conducted study was to analyse new materials intended for contact with the human body in view of their physical, chemical and biological properties. The authors have put to test six commercially available materials, four out of which were composite polyamide 12-based materials, while two were polyurethanes. The examined materials were assessed in terms of the surface. Subsequently, their hardness and biocompatibility were tested. The authors devoted major attention to the tests of absorption and emissivity of water, the pH = 7.4 PBS buffer solution and pH = 4.3 artificial sweat in temperatures of 21°C and 37°C. The results of the tests have confirmed the non-toxicity of all the tested materials and allowed to provide their characteristics in terms of their surface, hardness, as well as absorption and emissivity of various body fluids. Both polyamide 12 and the tested polyurethanes are classified as thermoplastics that may be used in additive technology.
18
Content available Osteoblasts response to novel chitosan/agarose/hydroxyapatite bone scaffold – studies on MC3T3-E1 and hFOB 1.19 cellular models
Kazimierczak Paulina, Vivcharenko Vladyslav, Truszkiewicz Wiesław, Wójcik Michał, Przekora Agata
Engineering of Biomaterials
|
2019
|
Vol. 22, no. 151
24--29
EN
Since it is known that various cell lines may ex-press different behaviours on the scaffolds surface, a comprehensive analysis using various cellular mo-dels is needed to evaluate the biomedical potential of developed biomaterials under in vitro conditions. Thus, the aim of this work was to fabricate bone scaffolds composed of a chitosan-agarose matrix reinforced with nanohydroxyapatite and compare the biological response of two cell lines, i.e. mouse calvarial preosteoblasts (MC3T3-E1 Subclone 4) and human foetal osteoblasts (hFOB 1.19). Within this study, the osteoblasts number on the scaffold surface and the osteogenic markers level produced by MC3T3-E1 and hFOB 1.19 cells were determined. Furthermore, changes in calcium and phosphorous ions concentrations in the culture media dedicated for MC3T3-E1 and hFOB 1.19 were estimated after the biomaterial incubation. The obtained results proved that the fabricated biomaterial is characterized by biocompatibility and osteoconductivity since it favours osteoblasts attachment and growth. It also supports the production of osteogenic markers (collagen, bALP, osteocalcin) by MC3T3-E1 and hFOB 1.19 cells. Interestingly, the developed biomaterial exhibits different ion reactivity values in the two culture media dedicated for the mentioned cell lines. It was also revealed that mouse and human osteoblasts differ in the cellular response to the fabricated scaffold. Thus, the use of at least two various cellular models is recommended to carry out a reliable biological characterization of the novel biomaterial. These results demonstrate that the tested bone scaffold is a promising biomaterial for bone regeneration applications, however further biological and physicochemical experiments are essential to fully assess its biomedical potential.
19
Content available Novel highly biocompatible chitosan/agarose film for potential application as skin substitute
Vivcharenko Vladyslav, Kazimierczak Paulina, Wójcik Michał, Przekora Agata
Engineering of Biomaterials
|
2019
|
Vol. 22, no. 153 spec. iss.
20
20
Content available Electrical and biological performance of oxygen and nitrogen modified CNTs
Benko Aleksandra, Popiela Tadeusz, Wilk Sabastian, Nocuń Marek, Bińczak Marta, Menaszek Elżbieta, Cruz David Medina, Webster Thomas J.
Engineering of Biomaterials
|
2019
|
Vol. 22, no. 153 spec. iss.
96
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