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Larwy Galleria mellonella a badanie patogenności mikroorganizmów

Sztucki D., Książczyk M.

Laboratorium - Przegląd Ogólnopolski

2018

nr 1

23--26

Owad Galleria mellonella wykazuje wiele cech, dzięki którym można go zaklasyfikować, jako organizm modelowy, przede wszystkim posiada mechanizmy odpowiedzi immunologicznej analogiczne do mechanizmów wrodzonych układu immunologicznego kręgowca. Oprócz innych typowych cech organizmu modelowego, Galleria mellonella może być inkubowana w temperaturze 37°C, dzięki czemu stanowi idealny model do badań nad patogennością mikroorganizmów. Użyteczność larw tego owada została poparta wieloma eksperymentami i naukowymi publikacjami.

Insect Galleria mellonella shows many features that make it possible to classify it as a model organism, above all it has mechanisms of the immune response analogous to the innate mechanisms of the immune system of the vertebrates. In addition to other typical features of the model organism, Galleria mellonella can be incubated at 37°C, making it an ideal model for the research on the pathogenicity of microorganisms. The usefulness of the insect’s larvae has been supported by many experiments and scientific publications.

In silico study of the structure and function of Streptococcus mutans plasmidic proteins

Caprari S., Minervini G., Brandi V., Polticelli F.

Bio-Algorithms and Med-Systems

2017

Vol. 13, no. 2

51--61

The Gram-positive bacterium Streptococcus mutans is the principal causative agent of human tooth decay, an oral disease that affects the majority of the world’s population. Although the complete S. mutans genome is known, approximately 700 proteins are still annotated as hypothetical proteins, as no threedimensional structure or homology with known proteins exists for them. Thus, the significant portion of genomic sequences coding for unknown-function proteins makes the knowledge of pathogenicity and survival mechanisms of S. mutans still incomplete. Plasmids are found in virtually every species of Streptococcus, and some of these mediate resistance to antibiotics and pathogenesis. However, there are strains of S. mutans that contain plasmids, such as LM7 and UA140, to which no function has been assigned yet. In this work, we describe an in silico study of the structure and function of all the S. mutans proteins encoded by pLM7 and pUA140 plasmids to gain insight into their biological function. A combination of different structural bioinformatics methodologies led to the identification of plasmidic proteins potentially required for the bacterial survival and pathogenicity. The structural information obtained on these proteins can be used to select novel targets for the design of innovative therapeutic agents towards S. mutans.