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Additive manufacturing methods, materials and medical applications - the review

Laskowska Dorota, Mitura Katarzyna, Ziółkowska Ewa, Bałasz Błażej

Journal of Mechanical and Energy Engineering

2021

Vol. 5, No 1

15--29

The aim of the additive manufacturing (AM) is a production of physical objects by adding material layer-by-layer based on virtual geometry developed in the computer system. The main criteria for the division of additive manufacturing methods are the way to apply the layer and the type of construction material. In most projects, the choice of method is a compromise between costs and properties (e.g. physical, chemical or mechanical) of the manufactured object. Currently, AM methods have found application in many areas of life, including industrial design, automotive, aerospace, architecture, jewellery, medicine and veterinary medicine, bringing many innovative and revolutionary solutions. The purpose of this article is to review of the additive production methods and present the potential of medical application.

Nanotechnology in oncology - current state of knowledge

Laskowska Dorota, Ziółkowska Ewa, Mitura Katarzyna

Engineering of Biomaterials

2019

Vol. 22, no. 152

2--9

Nanotechnology is an interdisciplinary area of science devoted to the production and testing of nanostructures - defined as forms of the matter organizations the size of which does not exceed 100 nm. It is a quickly developing area of science with many applications in different areas of life, for example in engineering, computing, medicine, pharmacy, andagriculture. One of the problems of contemporary oncology is the low specificity of applied therapies. Most currently used chemiopharmaceuticals have systemic effects which not only affect cancer cells but alsohealthy tissues. Complications after chemotherapy observed in many patients are bone marrow deficiency(neutropenin, thrombocytopenia, anemia), damageto the nervous system (neurotoxicity), myocardium(cardiotoxicity) and pulmonary parenchyma. Similarly, in radiotherapy, ionizing radiation destroys the healthy tissues in the irradiation field. The side effects of radiation therapy may include fatigue, skin reactions, and impairment of tissue and organ functions. According to studies, nanostructures are an opportunity to overcome these limitations. The most popular nanostructures used in medicine are liposomes, silver and gold nanoparticles, magnetic nanoparticles, carbonnanotubes, and dendrimers. The purpose of this article is to present the current state of knowledge on the use of available nanotechnology solutions in pharmacology and cancer treatment.