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1 Bulletin of the Polish Academy of Sciences. Chemistry

1 1999

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Interaction in mixed amphotericin B / sterols monolayers spread at the air / water interface

Dynarowicz-Łątka P., Seoane J. R., Trillo J. M., Mouzo O. C., Parada M. C.

Bulletin of the Polish Academy of Sciences. Chemistry

1999

Vol. 47, No.2

153-166

Different methods for studying molecular interaction between film-forming components in Langmuir monolayers were applied and compared for the mixed systems of amphotericin B with four different sterols: cholesterol, ergosterol, stigmasterol and B-sitosterol. Among the sterols studied, ergosterol exhibits the strongest interaction with amphotericin B and B-sitosterol the weakest. Cholesterol and stigmasterol show interme-diate behaviour. As a consequence of the interactions, deviations from ideality are ob-served; negative at low and positive at high surface pressures. 1'he interactions are most pronounced for monolayers with the mole fraction of amphotericin Xa == 0.5 and 0.7 which lea.ds to the formation of an amphotericin B-sterol complexes of 2:1 stoichiometry. The obtained results support pharmacological assumption that amphotericin B has a greater affinity to ergosterol than to other sterols. Also the presence of amphotericin B-sterol com-plexes of 2: 1 stoichiometry, responsible for the formation of channels in cell membranes, has been confirmed.