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Biofunctional impact of textured coatings in the application of heart assist therapy

Kurtyka Przemysław, Kopernik Magdalena, Kaczmarek Marcin, Surmiak Marcin, Major Łukasz, Kustosz Roman, Więcek Justyna, Kurtyka Klaudia, Bartkowiak Amanda, Major Roman

Archives of Civil and Mechanical Engineering

2023

Vol. 23, no. 1

art. no. e31, 2023

Due to a lack of organs, cardiac support systems are being implanted in patients with severe congestive heart failure. One of the solutions to overcome complications such as infow obstruction or pump thrombosis, which may occur in the case of ventricular assist devices, is to modify the surface of cannulas for the controlled blood clotting process. The results obtained up till now for developed surface coatings clearly show the influence of topographical and mechanical parameters of the coatings on cell viability and protein adsorption mechanism. The new coatings should enable the controlled growth of scar tissue, resulting in the limitation of thromboembolic events, and the reduction of cystic tissue growth into the fow lumen. The aim of this study is to evaluate the correlation between surface topography parameters on the susceptibility of cells to grow and adhere to the substrate as a solution with potential for use in MCS (mechanical circulatory support) devices. Research on surfaces used in MCS devices and on inflow cannulas has been carried out for many years, while the novelty of the present solution makes it a milestone within that type of application simultaneously allowing for appropriate selection of process parameters. Surface modifcation of titanium alloy Ti6Al7Nb was carried out using vacuum powder sintering of CP-Ti (commercially pure titanium) powder with two morphologies (regular spheres and irregular grains). The characterization of coatings obtained with the proposed method and the influence of measured topographic parameters (applying scanning electron microscopy, contact angle measurement and contact proflometry) on the cytotoxicity and susceptibility to protein adsorption were presented. Advanced albumin adsorption studies have fully confrmed the dependence of surface complexity on protein adsorption. The obtained results show a high potential of the produced coatings toward enabling permanent integration at the implant with the soft tissue.

Effect of textured surface topography parameters on cells proliferation and tissue growth in the mechanical circulatory support application

Kurtyka Przemysław, Major Roman, Kustosz Roman, Zalewski Jerzy, Wiecek Justyna, Bartkowiak Amanda, Kaczmarek Marcin, Joszko Kamil, Grajoszek Aniela

Engineering of Biomaterials

2021

Vol. 24, no. 163

Comparative study on mechanical and bioactive properties of different nanopatterned TiO2 substrates

Bartkowiak Amanda, Zarzycki Arkadiusz, Kąc Sławomir, Perzanowski Marcin, Marszałek Marta

Engineering of Biomaterials

2020

Vol. 23, no. 158 spec. iss.