Wyniki wyszukiwania - BazTech

Ograniczanie wyników

2 2023

Znaleziono wyników: 2

Liczba wyników na stronie

Wyniki wyszukiwania

Sortuj według:

Ogranicz wyniki do:

Raman scattering study of meloxicam molecule and DFT calculations of its possible conformers

Skonieczny Robert, Osmałek Tomasz, Froelich Anna, Wiśniewska Maria, Nowicka Ariadna B., Szybowicz Mirosław

Inżynieria Materiałowa

2023

Vol. 44, nr 5

16--25

Celem przeprowadzonych badań dla meloksykamu (MLX) było uzyskanie informacji o możliwych izomerach konformacyjnych oraz stabilności termicznej wybranych konformerów MLX. Obliczenia z wykorzystaniem teorii funkcjonału gęstości (DFT) wskazują na cztery możliwe izomery konformacyjne, które zostały porównane z eksperymentalnym widmem ramanowskim leku. Otrzymane wyniki wskazują, że konformer meloksykamu obserwowany w analizowanej próbce jest stabilny w badanym zakresie temperatur.

The aim of the performed studies for meloxicam (MLX) was to obtain information about possible conformational isomerism and the thermal stability of the selected conformers of MLX. Density functional theory (DFT) calculations show four possible conformational isomers which are compared to the experimental Raman spectrum of the drug. The obtained results indicate that the conformer of meloxicam observed in the analyzed sample is stable within the investigated temperature range.

Geometrical Accuracy and Strength of Micro-Needles Made of Polylactide by Fused Filament Fabrication Method

Wichniarek Radosław, Kuczko Wiesław, Tomczak Dorota, Nowicka Ariadna B., Wojtyłko Monika, Froelich Anna, Osmałek Tomasz

Advances in Science and Technology. Research Journal

2023

Vol. 17, no 6

116--126

Additive manufacturing is a technology that can be successfully used in pharmacy and medicine. One of the examples of products that can be additively manufactured are microneedle systems. The specificity of these products, which are used for transdermal drug delivery, makes additive manufacturing a perfect choice for related research. However, the dimensions of microneedles usually do not exceed 2 mm, which means that manufacturing them using the most widely available additive manufacturing method, Fused Deposition Modelling (FDM), is problematic. In this study, the authors decided to investigate the possibilities of manufacturing microneedle systems using the FDM method in such a way as to minimize or exclude the need for post-processing. Five types of microneedle geometries were tested in four sizes, examining how changing the values of FDM process parameters would affect the accuracy of reproducing the digital geometry of the microneedles. From the point of view of the application of microneedle systems, it is not only necessary to obtain the designed shape of the microneedles, but also to maintain their appropriate strength. The study presents the results of the bending and compression strength of microneedles made of polylactic acid.