The structures of diastereisomers obtained in bromomethylation reaction of title compounds have been investigated with the use of NOE difference NMR method and semi-empirical AM1 calculations.
The effective procedure of preparation of 2-trifluoromethyl-4,5-dicyanoimidazole (3a) from diaminomaleonitrile (1) and trifluoroacetic anhydride has been elaborated. The syntheses of five other 2-substituted imidazoles from appropriate acyl derivatives of 1 have been attempted. Out of them only 4,5-dicyanoimidazole (3b) could be obtained in good yield.
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