The presence of three dimensional support is indispensable condition for successful regeneration of the tissue. In the absence of natural scaffold, or absence of its artificial substitute, regeneration is not possible. The advantage of natural building blocks to create new scaffolds results from the requirements of the materials structures used for tissue regeneration: biocompatibility, biodegradability, lack of cytotoxicity and desirable mechanical properties. Application of these building blocks for the preparation of three dimensional materials should ensure completely biocompatibility of the temporary extracellular matrix equivalent, thus offering construct resembling a natural milieu for the cells and finally regeneration of tissues. These include framework with elements stimulating adhesion of in vitro grown cells, growth factors, hormones and vitamins offered as a completed ingredients in the commercially available culture media. 3D frameworks applied for cell growing should facilitate formation of required tissue shape and size as well as appropriate functioning of the cells. The key factor for the successful regeneration of tissues is the function of the scaffold determining the environment for growing cells, directing proliferation and regulating differentiation processes. The basic feature of the cellular scaffold, determining its functioning is porosity. Pore diameter and their abundance consists a critical factor for penetration of cells into the interior of the implant and finally for successful regeneration of damaged tissue. The progress of tissue regeneration in vitro depends on the presence of cytokines and growth factors, which are controlling cell differentiation process. Nowadays neither of implant material offered on the market has a property comparable to the natural tissue. However, there are many reports presenting preliminary experiments conducted towards attaining novel supports for regenerative medicine derived from peptides and formed by their self-organization. The most advanced of them are known under trade name PuraMatrix, which recently were applied for the regeneration of soft tissues. However, due to tendency of this materials for hydrogels formation, characteristic for them are disadvantageous mechanical properties. The alternative approach based on application of native ECM proteins was also taken into consideration. The weak points of this materials are the susceptibility of proteins towards proteolytic enzymes and theirs immunogenic properties. The diversity of peptide modules give the opportunity to design and synthesize a variety of biomaterials that mimic the structural complexity of the natural ECM.
Ekologia – to modne w ostatnich czasach hasło jest odmieniane przez wszystkie przypadki i może wydawać się już doskonale znane, zrozumiałe i takie oczywiste. Ale czy na pewno wiadomo, co kryje się pod tym terminem? Nawet jeśli rzeczywiście czuje się i rozumie ekologię, a nawet stara się na co dzień być „ekologicznym”, to niewątpliwe można na tę dziedzinę życia spojrzeć z jeszcze innej strony, podejść do niej bardziej refleksyjnie, a nawet artystycznie.
Można o nim mówić wiele – dla jednych to kolejne hasło nawiązujące do ekologii, które traktują z przymrużeniem oka, dla innych to styl życia, a dla niektórych to odpady, które należy posegregować