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Semantic web techniques for clinical topic detection in health care

Raman R., Sahayaraj Kishore Anthuvan, Soni Mukesh, Nayak Nihar Ranjan, Govindarajan Ramya, Singh Nikhil Kumar

Computer Assisted Methods in Engineering and Science

2024

Vol. 31, no. 2

139--155

The scope of this paper is that it investigates and proposes a new clustering method thattakes into account the timing characteristics of frequently used feature words and thesemantic similarity of microblog short texts as well as designing and implementing mi-croblog topic detection and detection based on clustering results. The aim of the proposedresearch is to provide a new cluster overlap reduction method based on the divisions ofsemantic memberships to solve limited semantic expression and diversify short microblogcontents. First, by defining the time-series frequent word set of the microblog text, a fea-ture word selection method for hot topics is given; then, for the existence of initial clusters,according to the time-series recurring feature word set, to obtain the initial clustering ofthe microblog.

Synthesis, Characterization, DNA Binding and Cleavage Studies of Some Novel Biosensitive Transition Metal(II) Complexes

Raman R., Joseph J.

Polish Journal of Chemistry

2007

Vol. 81, nr 7

1303-1311

Four novel Knoevenagel type Cu(II), Ni(II), Co(II) and Zn(II) macrocyclic complexes derived from 3-cinnamalideneacetoacetanilide and N-(2-aminoethyl)-1,3-propanediamine have been synthesized. The nature of complexes and the geometry have been inferred from their microanalytical data, magnetic susceptibility measurements, IR, UV-Vis., 1H NMR, ESR and mass spectral techniques. The low electrical conductance of complexes supports their neutral nature.Monomeric nature of the complexes is assessed from theirmagnetic susceptibility values. The in vitro biological screening effects of the investigated compounds were tested against the bacteria E. coli, S. aureus, S. typhi and K. pneumoniae by the well diffusion method using agar nutrient as the medium. A comparative study of MIC values of the macrocyclic Schiff base ligand and its complexes indicates that the complexes exhibit higher antibacterial activity than the free ligand. The cyclic voltammetry method was used to probe the interaction of a Cu(II) complex with pUC18 DNA. Information of the binding ratio and intercalation mode can be obtained from its electrochemical data. Cyclic voltammetric measurements showed that Cu(II) complex undergoes a reversible reduction at biologically accessible potentials. From the study, it is understood that copper complex prefers to bind with DNAin Cu(II) rather than Cu(I) oxidation state. The DNAcleavage ability of the complexes was monitored by gel electrophoresis using super coiled pUC18 DNA in Tris-HCl buffer.