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Properties of biodegradable polymer coatings with hydroxyapatite on a titanium alloy substrate

Goldsztajn Karolina, Godzierz Marcin, Hercog Anna, Władowski Mariusz, Jaworska Joanna, Jelonek Katarzyna, Woźniak Anna, Kajzer Wojciech, Orłowska Ada, Szewczenko Janusz

Acta of Bioengineering and Biomechanics

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2024

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Vol. 26, no. 1

121--132

EN

Titanium alloys are among the most widely used materials in medicine, especially in orthopedics. However, their use requires the application of an appropriate surface modification method to improve their properties. Such methods include anodic oxidation and the application of polymer coatings, which limit the release of alloying element ions. In addition, biodegradable polymer coatings can serve as a carrier for drugs and other substances. The paper presents the results of research on the physical properties of biodegradable polymer coatings containing na-noparticle hydroxyapatite on a titanium alloy substrate. Methods: A PLGA coating was used in the tests. The coatings on the substrate of the anodized Ti6Al7Nb alloy were applied by ultrasonic spray coating. The tests were carried out for coatings with various hydroxyapatite content (5, 10, 15, 20%) and thickness resulting from the number of layers applied (5, 10, 15 layers). The scope of the research included microscopic observations using scanning electron microscopy, topography tests with optical profilometry, structural studies using X-ray diffraction, as well as wettability and adhesion tests. Results: The results shows that with the use of ultrasonic spray coating system is possible to obtain the continuous coatings containing hydroxyapaptite. Conclusions: The properties of the coating can be controlled by changing the percentage of hydroxyapatite and the number of layers of which the coating is composed.

2

Mechanical Properties of Polymer Coatings Containing HAp and Active Substance on a Metal Substrate

Goldsztajn Karolina, Lisoń-Kubica Julia, Jaworska Joanna, Jelonek Katarzyna, Kajzer Wojciech, Szewczenko Janusz

Tribologia

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2023

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nr 2

17--25

EN

Titanium alloys are currently widely used in implantation, especially in orthopaedics. However, undesirable reactions caused by aluminium and vanadium ions released from the surface of the most commonly used alloys, Ti6Al4V and Ti6Al7Nb, result in the need to modify the surface of the material to improve biocompatibility. Among the available modification methods, one can mention the application of biodegradable polymer coatings, which, apart from improving biocompatibility by limiting the penetration of alloying element ions into the tissue environment, can also be a matrix for the release of mineral (HAp) and active substances. The paper attempts to determine the mechanical properties of PLGA polymer coatings containing nanoparticle hydroxyapatite and an active substance (dexamethasone) applied with the ultrasonic spray coating method on a Ti6Al7Nb alloy substrate. The scope of the research included: surface topography testing using an optical profilometer, coating adhesion testing to the substrate using the scratch test method and tribological testing (Pin-On-Disc method).

PL

Stopy tytanu znajdują obecnie szerokie zastosowania implantacyjne, szczególnie w ortopedii. Jednakże niepożądane reakcje wywoływane przez jony glinu i wanadu uwalnianie z powierzchni najczęściej wykorzystywanych w praktyce stopów Ti6Al4V oraz Ti6Al7Nb skutkują koniecznością modyfikacji powierzchni materiału w celu poprawy biokompatybilności. Wśród dostępnych metod modyfikacji wymienić można nakładanie biodegradowalnych powłok polimerowych, które poza poprawą biokompatybilności poprzez ograniczenie przenikania jonów pierwiastków stopowych do środowiska tkankowego stanowić mogą także matrycę dla uwalniania substancji mineralnych (HAp) oraz aktywnych. W pracy podjęto próbę określenia własności mechanicznych powłok polimerowych z PLGA, zawierających nanocząsteczkowy hydroksyapatyt oraz substancję aktywną (deksametazon), nakładanych metodą natryskiwania ultradźwiękowego na podłoże ze stopu Ti6Al7Nb. Zakres przeprowadzonych badań obejmował badania topografii powierzchni z wykorzystaniem profilometru optycznego, badania adhezji powłok do podłoża metodą scratch test oraz badania tribologiczne (metoda Pin-On-Disc).

3

Physical properties of biodegradable polymers exposed to artificial plasma flow

Zegartowska Alicja, Stojko Mateusz, Joszko Kamil, Goldsztajn Karolina, Orłowska Ada, Szewczenko Janusz

Engineering of Biomaterials

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2023

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vol. 26, no. 170

9--13

EN

Despite significant advances in diagnosis and treatment, cardiovascular disease remains a major cause of premature death. Approximately 80% of cardiovascular incidents can be prevented by optimizing risk factor control and lifestyle modification, including dietary change. Treatment of cardiovascular disease, like treatment of other diseases, can be divided into conservative and curative. Conservative treatment is based on pharmacotherapy, while surgical treatment is mainly based on the use of PCI (percutaneous coronary intervention) procedures, i.e., increasing blood flow through narrowed arteries. This effect can be achieved with stents. The main limitation of metal stents is their permanent presence within the body, which can lead to complications such as thrombosis. A more advanced solution is the use of polymer or drug-coated stents, both of which are made of biodegradable materials. These stents are designed to release medications to support treatment and maintain their shape within the blood vessel before being naturally absorbed and eliminated by the body. In this study, the surface of stents made of polylactide was modified by applying a layer of PLGA using an ultrasound method. The study was carried out for uncoated and coated stents in both the initial state and after exposure to artificial plasma flow. The scope of the work included microscopic observations, weight measurements of the specimen, and examination of radial forces. The analysis of the results showed no clear effect of exposure on stent weight, but a clear effect of long- -term exposure on radial forces was observed.

4

Physical properties of materials used for infusion sets for photosensitive medicines

Szafarczyk Karolina, Szewczenko Janusz, Maciak Erwin, Kałużyński Piotr, Goldsztajn Karolina

Engineering of Biomaterials

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2022

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vol. 25, no. 167

2--9

EN

Continuous infusion, as one of the most effective methods of delivering pharmaceuticals to patients, uses infusion pumps to which a syringe and infusion drains are connected. Photosensitive drugs that require UV-VIS protection are delivered to patients with special infusion sets that reduce harmful radiation. However, these drains have different transparencies, which can affect the success of therapy. This study investigated the optical properties of two types of drains used for infusion therapy of photosensitive drugs. UV-VIS spectroscopy studies were carried out, allowing the determination of the absorbance values and absorption coefficient of the two types of drains. The spectrum of their transmittance was also analyzed. The chemical composition of the samples was tested using FTIR-ATR spectroscopy. Furthermore, the roughness and wettability parameters of the drains were determined, which affect not only the kinematics of drug flow in the drains but also the way in which light is transmitted. The results of the study can be used to propose a solution to eliminate the problem of loss of properties of the photosensitive drug in drains, in contact with light. By selecting the appropriate drain thickness, it is possible to reduce the transmission of radiation in the UV-VIS range through the drain.

5

Physical properties of PLGA biodegradable polymer coatings containing hydroxyapatite on Ti6Al7Nb substrate

Goldsztajn Karolina, Szewczenko Janusz, Jaworska Joanna, Jelonek Katarzyna, Basiaga Marcin

Engineering of Biomaterials

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2021

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Vol. 24, no. 163

31

6

Bioresorbable vascular scaffolds - effect of coating parameters on morphology and dose of antirestenotic drug

Jelonek Katarzyna, Jaworska Joanna, Musiał-Kulik Monika, Stojko Mateusz, Sobota Michał, Włodarczyk Jakub, Pastusiak Małgorzata, Szewczenko Janusz, Goldsztajn Karolina, Dobrzyński Piotr, Kasperczyk Janusz

Engineering of Biomaterials

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2021

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Vol. 24, no. 163

81

7

Atomic layer deposited ZnO films on stainless steel for biomedical applications

Basiaga Marcin, Walke Witold, Kajzer Wojciech, Sambok-Kiełbowicz Agata, Szewczenko Janusz, Simka Wojciech, Szindler Marek, Ziębowicz Bogusław, Lubenets Vira

Archives of Civil and Mechanical Engineering

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2021

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Vol. 21, no. 1

1--15

EN

The main goal of carried out tests were the impact of physicochemical properties of surface layers on the course of processes taking place on the surface of implants made of metallic biomaterials used in the bone system. As a precursor of ZnO, diethylzinc (DEZ) has been used, which reacted with water enabling the deposition of thin films. The chamber temperature was as follows—T = 200°–300 °C. The number of cycles was 500, 1000, and 1500. In the first stage, pitting corrosion test was carried out. Corrosion resistance has been tested under conditions simulating tissue environment. Moreover, the created layers were tested using electrochemical impedance spectroscopy (EIS). The conducted electrochemical tests showed the beneficial effect of the ZnO layer on the substrate made of 316 LVM steel, as evidenced by the obtained parameters describing the corrosion resistance. Furthermore, tests were performed on mechanical properties (scratch test), surface morphology (SEM and AFM method), and physical properties (wettability and thickness layers) for samples with different surface treatments. The investigations of the surface morphology of the applied ZnO layer using the ALD method showed a tendency to inherit the substrate independently of the used application parameters. On the other hand, the tests of adhesion to the substrate showed that the number of cycles of the application process has a fundamental impact on the adhesion of the applied layer to the substrate. Summarizing tests have clearly shown that the number of cycles and temperature in the case of the ZnO coating is significant and positively influences the increase of electrochemical, mechanical, and physical properties of layers.

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Biodegradable polymer coatings on Ti6Al7Nb alloy

Szewczenko Janusz, Kajzer Wojciech, Kajzer Anita, Basiaga Marcin, Kaczmarek Marcin, Antonowicz Magdalena, Nowińska Katarzyna, Jaworska Joanna, Jelonek Katarzyna, Kasperczyk Janusz

Acta of Bioengineering and Biomechanics

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2019

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Vol. 21, no. 4

83--92

EN

The aim of the study was to determine the influence of long term exposure to Ringer’s solution of biodegradable polymer coatings containing an active substance on the Ti6Al7Nb alloy substrate on the physical and chemical properties of the coatings and the degradation process of the metal substrate. The studies used poly(L-lactide-co-trimethylene carbonate) P(L/TMC), poly(L-lactide-co-trimethylene carbonate-glycolide) P(L/TMC/G) and poly(D,L-lactide-glycolide) (PLGA) coatings applied to the anodically oxidized Ti6Al7Nb alloy by means of dipping method (1, 2 and 3 dips). The polymer coatings contained ciprofloxacin. Roughness and wettability tests were carried out on the substrate and polymer coatings, the pitting corrosion resistance of the substrate and samples with polymer coating was determined, the number of metallic ions released to the solution from the coated and uncoated samples was determined as well as the adhesion of polymer coatings. The research was supplemented by microscopic observations. The results of the research indicate different influence of exposure to Ringer’s solution on the physical and chemical properties of biodegradable polymer coatings containing ciprofloxacin and the course of the degradation process of the metal substrate.