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Validation of HPLC Method for Quantitative Determination of Pirimiphos methyl

Tamilselvan C., Joseph S. J., Mugunthan G., Ahamed S.S. M.

International Letters of Chemistry, Physics and Astronomy

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2014

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Vol. 9

93--102

EN

The objective of this research to optimise the HPLC method was developed for quantitative determination of Pirimiphos-methyl. Chromatographic separation was achieved on a 250 x 4.6 mm i.d. reversed phase column Qualisil BDS 5u C18, Using deionized acetonitrile:water in the ratio of 85:15 v/v respectively as mobile phase. The eluent was monitored at 254 nm. A sharp peak was obtained for the Pirimiphos-methyl at 9.29 min. The UV Spectrophotometric method performed at 254 nm after full scan analysis using methanol as a solvent. The result revealed that both methods are suitable to carry out routine analysis of Pirimiphos methyl, However HPLC results showed high precise, accurate and sensitive than the UV Spectrophotometer. Hence HPLC method is suitable for trace analysis of Pirimiphos methyl in environmental samples.

2

Spectral correlation analysis of Hammett substituent constants and biological activities of some (E)-1-(4-phenoxyphenyl)-3-phenylprop-2-en-1-ones

Kalyanasundaram N., Sakthinathan S. P., Suresh R., Kamalakkannan D., Joseph S. J., Vanangamudi G., Thirunarayanan G.

International Letters of Chemistry, Physics and Astronomy

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2014

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Vol. 9

23--47

EN

A series of aryl chalcones have been synthesized from 4-phenoxyacetophonone with various substituted benzaldehydes. The purity of all chalcones has been checked using their physical constants and spectral data. These spectral data have been correlated with Hammett substituent constants and F and R parameters using single and multi-linear regression analysis. From the results of statistical analysis, the effect of substituents on the above spectral data has been studied. The single parameter correlation with few Hammett constants and F and R parameters gave satisfactory correlation coefficients whereas all multiple correlations gave satisfactory correlation coefficients with Resonance, Field and Swain-Lupton’s parameters. The antimicrobial activities of all chalcones have been studied using Bauer-Kirby method.

3

Spectral correlation analysis and antimicrobial activities of some 2,4-dimethoxy phenyl chalcones

Joseph S. J., Arulkumaran R., Kamalakkannan D., Sakthinathan S. P., Sundararajan R., Suresh R., Vijayakumar S., Ranganathan K., Kalyanasundaram N., Vanangamudi G., Thirunarayanan G.

International Letters of Chemistry, Physics and Astronomy

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2014

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Vol. 4

48--65

EN

A series of 2,4-dimethoxy phenyl chalcones have been synthesized by Crossed-Aldol condensation of 2,4-dimethoxy phenyl and various substituted benzaldehydes. The purities of these chalcones have been checked by their physical constants, UV, IR, NMR and MASS spectral data. The spectral data of these chalcones have been correlated with Hammett sigma constants, F and R parameters using single and multi-linear regression analysis. From the results of statistical analysis, the effects of substituents on the spectral group frequencies have been discussed. The anti-microbial activities of these chalcones have been evaluated using Bauer-Kirby method.

4

Assessment of substituent effects and antimicrobial activities of some 2ʹ,5ʹ-dimethyl phenyl chalcones

Joseph S. J., Kamalakkannan D., Arulkumaran R., Sakthinathan S. P., Suresh R., Sundararajan R., Vijayakumar S., Ranganathan K., Vanangamudi G., Thirunarayanan G.

International Letters of Chemistry, Physics and Astronomy

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2014

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Vol. 5

99-123

EN

Some 2ʹ,5ʹ-dimethyl phenyl chalcones have been synthesized by Crossed-Aldol condensation between 2,5-dimethyl acetophenone and various substituted benzaldehydes using catalytic amount of sodium hydroxide and ethanol. The yields of the chalcones are more than 93 %. The purities of these chalcones have been checked by their physical constants, UV, IR, NMR and MASS spectral data. The spectral data of these chalcones have been correlated with Hammett sigma constants, F and R parameters using single and multi-linear regression analysis. From the results of statistical analysis, the effects of substituents on the spectral group frequencies have been discussed. The anti-microbial activities of these chalcones have been evaluated using Bauer-Kirby method.