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1 2011

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Analytical microsystems for biomedical and environmental applications

Jaffrezic-Renault N., Errachid A.

Biocybernetics and Biomedical Engineering

2011

Vol. 31, no. 4

3-16

Two types of analytical microsystems for the detection of species of interest in biomedical diagnosis and in environmental monitoring are specifically described in this paper. We describe a novel device that will measure whole blood concentration of D-dimer, a recognized biomarker of increased blood clotting activity and that will then offer opportunity to use the test in the point of care setting. The device combines innovation in antibody bio-engineering for high specificity immunoassay-based diagnostics and nano/micro engineered impedimetric analysis electrodes incorporating a biocompatible polymer substrate with development of a disposable microfluidic manifold, enabling diagnostics at the point-of-first-contact. The feasibility of a generic microsystem integrating a microfluidic system of concentration and a module of electrochemical detection is demonstrated for the four metals of the European directive (OCE 2000/GO/EC) for the quality of water resource: cadmium, mercury, lead and nickeI.