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3 Inżynieria Biomateriałów

3 2004

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Resorbable multifunctional antibiotic releasing tacks

Tiainen J., Knuutila K., Veiranto M., Suokas E., Waris T., Tormala P., Kaarela O., Ashammakhi N.

Inżynieria Biomateriałów

2004

R. 7, nr 38-42

11-11

The aim of this study was to compare the pullout forces of recently developed bioabsorbable ciprofloxacin-releasing and plain self-reinforced polylactide/polyglycolide (SR-PLGA) 80/20 tacks in human cadaver parietal bones. Parietal bone pieces (approximately 6 x 20 cm) were collected from five human male cadavers (29-77 years of age). Fifty plain SR-PLGA 80/20 tacks (diameter = 2 mm, length = 6,0 mm) and 50 ciprofloxacin-releasing SR-PLGA 80/20 tacks of similar dimensions were applied to drill holes using a special tack-shooter without tapping the drill holes. The force needed to pull the tacks from human parietal cadaver bones was measured using a universal tensile testing machine. The tack pullout speed was 10 mm/min. Means and standard deviations (SDs) were calculated and analyzed using the Student t test (SPSS version 10.0 for Windows). The pullout forces of the ciprofloxacin-releasing and plain tacks were 147 +/- 10.3 N and 141.4 +/- 12.6 N respectively (insignificant difference, P<0.001). The main cause of failure was the breakage of tack barbs (95% in the both cases). Ciprofloxacin-releasing SR-PLGA tacks have a pullout strength similar to corresponding plain conventional SR-PLGA tacks and they can be applied in cranial bone fixation.

Overview of bioabsorbable biomaterials: development of multifunctional osteoconductive drug-releasing hard tissue fixation screws

Ashammakhi N., Veiranto M., Vitanen P., Knuutila K., Suokas E., Tiainen J., Leinonen S., Niemela S.-M., Waris T., Aro H., Törmälä P.

Inżynieria Biomateriałów

2004

R. 7, nr 37

42-42

Investigation of the effect of ciprofloxacin-releasing bioabsorbable implant on staphylococcus epidermidis attachment and biofilm formation in vitro

Niemela S.-M., Ikaheimo I., Koskela M., Veiranto M., Suokas E., Tormala P., Waris T., Ashammakhi N., Syrjala H.

Inżynieria Biomateriałów

2004

R. 7, nr 38-42

13-14