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Zastosowanie technik laserowej desorpcji/jonizacji w identyfikacji lipidów jako biomarkerów raka prostaty

Buszewska-Forajta Magdalena, Pomastowski Paweł Piotr, Maślak Ewelina, Fijałkowski Piotr, Buszewski Bogusław

Wiadomości Chemiczne

2021

[Z] 75, 7-8

893--909

Mass spectroscopy has grown enormously over the past century and its variations are used in many fields. One of the methods used to ionize particles is to irradiate the sample with laser radiation. This methods are called laser desorption/ionization techniques and they have great potential for diagnostic applications. Thanks to the so-called soft ionization, direct analysis of a wide variety of compound classes can be used for rapid profiling. Lipids are a diverse group of metabolites that share a common feature of having a hydrophobic fragment. They play an important role in various cellular processes. Changes in lipidome correlate with the symptoms of various diseases. The observation of abnormalities in lipid metabolism is especially important in cancers diagnosed in many patients - such as prostate cancer. Monitoring the level of key biomarkers in the development of a given disease will allow for an earlier correct diagnosis and the use of individual treatment. This short review presents the issues of prostate cancer and the applicability of laser desorption/ionization techniques to identify lipid biomarkers that can be used for rapid identification.