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1 International Letters of Chemistry, Physics and Astronomy

1 2014

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Synthesis and characterization of some new Schiff bases of 2-oxonaphtho[2,1-b][1,4]oxazine

Chovatiya P., Mehta C., Senjani H., Shah A., Joshi H. S.

International Letters of Chemistry, Physics and Astronomy

2014

Vol. 12

26--30

The literature review reveal that [1,4]-oxazine derivatives represent one of the most active classes of compounds possessing wide spectrum of biodynamic activities and use as potent therapeutic agents. In the present work, a series of Schiff base of 2-(2,3-dihydro-2-oxonaphtho[2,1-b][1,4]oxazin-1-yl)acetohydrazide, 5a-5j has been synthesized using 1-aminonaphthalen-2-ol. Various aromatic aldehyde were react with carbohydrazide 4 in the presence of acid to produce the 2-oxonaphtho[2,1-b][1,4]oxazin Schiff base derivatives with good yields. All synthesized compounds were characterized by IR, NMR and Mass spectrometry analysis.