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1 2014

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Preliminary study on the electrospun PLA–based nanofibres as biomaterials for the treatment of cartilage

Magiera A., Markowski J., Lesiuk M., Sieroń A. L, Pilch J., Błażewicz S.

Engineering of Biomaterials

2014

Vol. 17, no. 128-129

110--111

Electrospinning is a simple and universal way to produce fibres from a variety of materials having diameters ranging from submicrometers to nanometers. Such fibres can be formed from resorbable and non-resorbable polymers, ceramics and their different combinations containing nanoparticles. Such a method has gained a great interest in medicine due to its ability to form a fibrous space architecture, similar to the natural extracellular matrix [1,2]. On the other hand, due to a wide range of technical facilities of electrospun fibers the method allows to create directionally-dependent space architecture of nanofibres which mimic natural tissues [3]. Considering the similarities between the microstructure created by nanofibres and the extracellular matrix, nanofibrous materials made by ES technique seem to be promising scaffolds to regenerate cartilage [4] and neural tissue [5]. A material which is used for cartilage scaffolds should mimic native cartilage, which is known to have an oriented structure associated with its mechanical and physiological functions [5]. Scaffold with a biomimetic-oriented architecture is an important requirement for tissue-engineered cartilage. In this study, PLA oriented and non-oriented fibrous scaffolds were manufactured. Selected properties of the materials were analysed and dissussed in view of the manufacture of optimal structure for cartilage tissue engineering.