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Nukleozydo i oligonukleozydo boranofosfoniany : metody syntezy i wybrane właściwości biologiczne

Gołębiewska Justyna

Wiadomości Chemiczne

2020

[Z] 74, 7-8

477--506

Interest in boron-containing compounds has grown in recent years due to their potential medicinal and biochemical applications. Nucleoside boranephosphonates are analogues of naturally occurring nucleoside phosphates in which one of the non- bridging oxygen atom has been replaced by a BH3 group [1]. This modification imparts unique biological properties to nucleotides and nucleic acids. DNA and RNA fragments containing boranephosphonate internucleotide linkages are resistant to various nucleases, stimulate the RNase H activity, and reveal high lipophilicity, which significantly enhances their cellular uptake [2]. The hydrolytic stability and nuclease resistance make these compounds attractive candidates in designing new therapeutics and medicinal diagnostics. Considering these characteristics nucleoside boranephosphonates constitute a promising class of nucleotide analogues worth exploring for biological purposes.