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Fluid–structure interaction simulation for studying hemodynamics and rupture risk of patient-specific intracranial aneurysms

Chang Ruan, Qi Yu, Jingyuan Zhou, Xinying Ou, Yi Liu, Yu Chen

Acta of Bioengineering and Biomechanics

2023

Vol. 25, no. 3

The role of regional hemodynamics in intracranial aneurysms (IAs) hemodynamics and rupture risk has been widely discussed based on numerical models over the past decades. The aim of this paper is to investigate hemodynamics and rupture risk with a complicated IA model. Fluid-structure interaction (FSI) simulations were performed to quantify the hemodynamic characteristics of the established IA models. Hemodynamic parameters, including wall shear stress (WSS), flow velocity, and flow pattern, were calculated and analyzed. In this paper, the risk assessment of intracranial aneurysms focuses on the mechanical properties of blood flow and blood vessel walls. Vortex flow and concentrated impact field during blood flow play a decisive role in the rupture and development of aneurysms. The uneven distribution of wall shear stress on the vessel wall has a great influence on growth and rupture. By observing the simulation results of rigid walls, risks can be predicted efficiently and accurately. This paper focuses on the relationship between hemodynamics and rupture risk with a double intracranial aneurysms disease mode and provides a new perspective on the treatment of intracranial aneurysms.

Synthesis of antibacterial polyurethane film and its properties

Lin Zhao, Yunyun Li, Bin Cheng, Yu Chen

Polish Journal of Chemical Technology

2020

Vol. 22, nr 2

50--55

Polyurethane (PU) is a polymer widely used in the biomedical field with excellent mechanical properties and good biocompatibility. However, it usually exhibits poor antibacterial properties for practical applications. Efforts are needed to improve the antibacterial activities of PU films for broader application prospect and added application values. In the present work, two PU films, TDI-P(E-co-T) and TDI-N-100-P(E-co-T), were prepared. Silver nanoparticles (AgNPs) were composited into the TDI-N-100-P(E-co-T) film for better mechanical properties and antibacterial activities, and resultant PU/AgNPs composite film was systematically characterized and studied. The as-prepared PU/AgNPs composite film exhibits much better antibacterial properties than the traditional PU membrane, exhibiting broader application prospect.