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1 International Letters of Chemistry, Physics and Astronomy

1 2013

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Synthesis of some butenolides and study of their antibacterial activity

Tamma N., Gherraf N.

International Letters of Chemistry, Physics and Astronomy

2013

Vol. 9, iss. 1

61-67

Butenolides and their analogues represent a wide range of natural compounds of a medical and biological importance. In the last decades, a great number of compounds of various structures, in general from Alkylidene butenolide, were isolated and showed biological activities. In this work we have studied the reactivity of some alkylidene butenolide and their antibacterial activity. the study is of a scientific interest in terms of the synthesis of new compounds (Butenolide 01: 5-hydroxy-5-(1-methoxypropan-2-yl)-4-methylfuran-2(5H)-one, Butenolide 02: 5-(1-methoxypropan-2-yl)-4-methylfuran-2(5H)-one) that have not been studied before by other researchers; and of an economic importance because of its synthesis process which is easy and inexpensive. Moreover, butenolide showed a positive antimicrobial activity (antibiotic) against pathogenic bacteria (mainly Enterobacter hafniae).