antioxidant activity, and antimicrobial effects of various fractions of Corrigiola telephiifolia Pourr. roots collected from three distinct regions in Morocco. The obtained results reveal significant variations in TPC, TFC, and antioxidant activity depending on the extraction fraction and geographic origin. Notably, the fraction of raw extract exhibited the highest TPC values in all sampled sites (44.76 ± 0.05 in Agouray, 35.89±0.02 in Sefrou, and 14.99 ± 0.03 mg·GAE/g·dw in Azrou). The peak values of TFC were recorded in the fraction of raw extracts for all sampling sites (20.80 ± 0.01 in Agouray, 18.62 ± 0.01 in Sefrou, and 11.54 ± 0.01 mg QAE/g dw in Azrou). The highest values of FRAP were recorded in the fraction of raw extract of Agouray (2.00±0.00). Furthermore, the hexane fraction showed the highest DPPH and Chelating power with IC50 equal to 0.46 ± 0.02 mg·mL-1 and 0.10 ± 0.00 mg·mL-1, respectively. All fractions showed significant and variable antibacterial activities. The highest antimicrobial activity was recorded in in ethyl acetate fraction of the sample from Agouray against E. coli (MIC = 0.039). The highest anti-microbial effect was recorded also in ethyl acetate fraction against E. coli and P. aeruginosa, and raw fraction against B. subtilis and P. aeruginosa (MBC = 0.313 against both microorganisms). Agouray consistently demonstrated superior results across multiple parameters, indicating it as the best region for the highest phytochemical and bioactive properties. This study evaluated the chemical compounds and biological properties of Corrigiola. telephiifolia Pourr. and demonstrated the effect of the sampled area and solvent.

traditional uses, and pharmacological properties of Corrigiola telephiifolia Pourr. Through an exhaustive search of primary databases, literature from 1950 to 2022 was examined, focusing on keywords to ensure inclusivity. The plant exhibits diverse physiological functions, potentially aiding in the prevention of diabetes, dyslipidemia, oxidative stress, and microbial infections while enhancing immunity. Similarly, we outlined recommendations for future research aimed at addressing existing gaps, and additional comprehensive studies are necessary to investigate the influence of climate change and other factors on the variability of chemical constituents. These endeavors would provide fresh perspectives on the biological characteristics of this species and offer guidance for future research initiatives.