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1
Content available remote HPLC analysis and detection of l-deprenyl
Csomor V., Laufer R., Pöstényi Z., Kalász H., Adeghate E., Nurulain S. M., Tekes K., Adem A.
Acta Chromatographica
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2014
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Vol. 26, no. 4
649--656
EN
l-Deprenyl and its major metabolites were subjected to reversed-phase high-performance liquid chromatography (HPLC). The separation was monitored using both ultraviolet (UV) and electrochemical detectors. Ultraviolet absorbance detected l-deprenyl, l-nordeprenyl, l-methamphetamine, and l-amphetamine. Amperometric detection was specific and sensitive to the parent compound (l-deprenyl, a tertiary amine) only. Peaks of the major L-deprenyl metabolites did not give any comparable signal using amperometric monitoring.
2
Content available remote HPLC monitoring of the microsomal stability of rutin and quercetin
Szőke É, Petroianu G., Tekes K., Benkő B, Szegi P., Laufer R., Veress G
Acta Chromatographica
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2009
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Vol. 21, no. 3
399--410
EN
Reversed-phase HPLC has been used to monitor the concentration of the two major Chamomile components rutin and quercetin during rat liver microsomal treatment. The possibility of microsomal oxidative metabolism or stability of these two components was examined using a guard-column without any clean-up. The concentration of quercetin decreased when exposed to rat liver microsomal media whereas the rutin concentration did not change significantly over one hour of treatment.
3
Content available remote HPLC study of the pharmacokinetics of K-203
Kalász H., Laufer R., Szegi P., Kuca K., Musilek K., Tekes K.
Acta Chromatographica
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2008
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Vol. 20, no. 4
575-584
EN
The pharmacokinetics of K-203, a recently synthesized bis-pyridinium aldoxime, have been investigated by reversed-phase HPLC. The K-203 content of serum samples was monitored by HPLC with ultraviolet absorbance detection at 286 nm. The low concentration of K-203 in samples of brain, eyes, and cerebrospinal fluid was also determined by HPLC; quantitative evaluation was possible by use of an amperometric detector.
4
Content available remote HPLC analysis of microsomal metabolism of K-48
Benkő B., Laufer R., Ohmacht R.
Acta Chromatographica
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2007
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No. 19
61-72
EN
K-27 and K-48, bisquaternary pyridinium aldoximes differing only in the number of methyl units in the alkyl bridges between the two quaternary nitrogen atoms, are promising candidates for use as potent and effective antidotes to organophosphate intoxication. K-27 and K-48 were treated with rat hepatic microsomal preparations from healthy (control) and diabetic animals. Microsomal metabolism was measured at different times up to 45 min. This treatment resulted in a decrease of approximately 30% in the concentration of K-48 whereas that of K-27 was unchanged. There was no significant difference between the effects of microsomal preparations from control and diabetic rat liver. K-27 and K-48 in a variety of media were analysed by reversed-phase HPLC with both ultraviolet and electrochemical detection. The method was validated by the usual procedures.
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