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Adhesion and proliferation of vascular smooth muscle cells on polylactide-polyethylene oxide copolymers with different content and length of polyethylene oxide chains

Filova E., Bacakova L., Lisa V., Kubies D., Machova L., Lapcikova M., Rypacek F.

Inżynieria Biomateriałów

2004

R. 7, nr 38-42

19-21

We evaluated antiadhesive effects of polymer surfaces prepared from PDLLA-PEO copolymers using PEO with a different molecular weight and different PEO content in comparison with the native poly(L-lactide) (PLLA) surface. All PDLLA-PEO copolymers significantly decreased number of initially adhered cells (by 23-55% in comparison with pure PLLA) as well as spreading area 24 hours after seeding (by 39-79%). Cell proliferation, estimated by cell number on the 6 day after seeding and bromodeoxyuridine (BrdU) labeling index, was significantly lower on PEO-containing copolymers (by 58-96% and 21-35% respectively) compared to pure PLLA surface. Immunofluorescence staining of vinculin showed that the ability of VSMC to form local adhesion plaques was markedly reduced on surfaces with the highest content of PEO (33 and 44%). Thus, these copolymers are promising for creation of surfaces preventing uncontrolled adsorption of proteins and adhesion of cells. Consecutively, binding of defined ligands for cell adhesion receptors would enable to control cell behaviour on these materials, which could be used for construction of vascular prostheses.

Vascular smooth muscle cells in cultures on lactide based polymers for potential construction of artificial vessel wall

Filova E., Bacakova L., Lisa V., Machova L., Lapcikova M., Kubies D., Proks V., Rypacek F.

Inżynieria Biomateriałów

2003

R. 6, nr 30-33

9-11