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1
Content available Walther H. Nerst : chemik, innowator, człowiek
Buszewski Bogusław
Wiadomości Chemiczne
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2023
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[Z] 77, 9-10
817--832
2
Content available remote The influence of selected transition elements on cell metabolism
Terpiłowska Sylwia, Rafińska Katarzyna, Gołębiowski Adrian, Kowalkowski Tomasz, Buszewski Bogusław
Ecological Chemistry and Engineering. S
|
2023
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Vol. 30, nr 4
471--488
EN
The elements are present in the environment. Moreover, they are used in pharmacy and the production of new materials used in medical applications. They are often as environmental pollutants. They can accumulate in organisms and induce toxic effects on the cellular level. HepG2, L929 and Caco-2 cell lines were exposed to known concentrations of chromium chloride, iron chloride, nickel chloride, molybdenum trioxide and cobalt chloride (200 or 1000 μ M used alone and in combinations). Concentrations of chromium, iron, nickel, molybdenum and cobalt in the cell lysate and the culture medium were determined by ICP-MS. Moreover, sodium, potassium, calcium and magnesium concentrations were also measured. What is more, cells were observed under light and scanning electron microscope. The dose-dependent increase in the concentration of chromium, iron, nickel, molybdenum and cobalt in all cell lines after incubation with elements was observed. Potassium concentration decreases while sodium calcium and magnesium increase after incubation of cells with of mentioned elements. The incubation of cells with microelements induces cell morphology changes. The presented study shows the crucial role of tested microelements in the induction of cell death as a result of an imbalance of sodium, potassium, calcium and magnesium concentration inside the cell.
3
Content available Analityka antybiotyków β-laktamowych w układzie in silico, in vitro oraz in vivo
Janiszewska Daria, Szultka-Młyńska Małgorzata, Buszewski Bogusław
Wiadomości Chemiczne
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2022
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[Z] 76, 3-4
109--127
EN
Drug analysis necessitates introducing selective methods of detection and enriching the substances present in biomaterial at low concentration levels (trace analysis). Moreover, there is a continuous demand for increase in the quality of drugs that are being developed, which in turn enforces the development of analytical techniques of increasing sensitivity and accuracy with the applicationof combined separation techniques. Thus the premise of this review is to comparethe in vitro metabolic pathways of antibiotic drugs in model conditions such as in the presence of different microsomal fraction enzymes and with the applicationof electrochemical stimulation of metabolic transformations, as well as to the collected data with the results of in vivo experiments.
4
Zastosowanie techniki MIP-SPME do terapeutycznego monitorowania leków w próbkach biologicznych
Janiszewska Daria, Szultka-Młyńska Małgorzata, Buszewski Bogusław
Analityka : nauka i praktyka
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2022
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nr 2
10--19
PL
Terapeutyczne monitorowanie leków oraz ich aktywnie farmakologicznych metabolitów umożliwia ocenę ich farmakokinetyki i metabolizmu, jak również ustalenia odpowiedniego dawkowania pod kątem terapii pacjenta. Technika MIP-SPME stwarza nowe możliwości w zakresie selektywnej ekstrakcji leków i ich potencjalnych metabolitów.
5
Napoje funkcjonalne, czyli małe laboratorium zamknięte w puszce lub butelce
Sugajski Mateusz, Buszewski Bogusław
Analityka : nauka i praktyka
|
2022
|
nr 3
37--48
PL
W ciągu zaledwie 50 lat istnienia napojów sportowych udowodniono naukowo ich skuteczność w szybkim uzupełnianiu energii i płynów w organizmie, co bezpośrednio przekłada się na zwiększanie wydajności. Z tajnej broni sportowców stały się wielomiliardową branżą, dostępną i rozpowszechnioną na rynku globalnym.
6
Fizykochemiczne techniki rozdzielania w Polsce
Buszewski Bogusław
Analityka : nauka i praktyka
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2022
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nr 1
36--46
PL
W niniejszym opracowaniu przedstawione zostaną najważniejsze osiągnięcia, jakie zostały uzyskane w budowie „polskiej” szkoły chromatograficznej w poszczególnych ośrodkach akademickich: Lublina, Warszawy, Gdańska, Poznania, Łodzi, Śląska, Krakowa czy Torunia.
7
Dzieje Komitetu Chemii Analitycznej w 70-leciu Polskiej Akademii Nauk
Staneczko-Baranowska Irena, Gadzała-Kopciuch Renata, Buszewski Bogusław
Analityka : nauka i praktyka
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2022
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nr 2
58--64
PL
Komitet Chemii Analitycznej PAN jest jednym z 12 komitetów naukowych PAN. Powołany został w 1975 roku, jednak swoją historię datuje już od 1955 roku, kiedy to utworzono Komisję Analityczną przy Komitecie Nauk Chemicznych Polskiej Akademii Nauk.
8
Content available Zastosowanie technik laserowej desorpcji/jonizacji w identyfikacji lipidów jako biomarkerów raka prostaty
Buszewska-Forajta Magdalena, Pomastowski Paweł Piotr, Maślak Ewelina, Fijałkowski Piotr, Buszewski Bogusław
Wiadomości Chemiczne
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2021
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[Z] 75, 7-8
893--909
EN
Mass spectroscopy has grown enormously over the past century and its variations are used in many fields. One of the methods used to ionize particles is to irradiate the sample with laser radiation. This methods are called laser desorption/ionization techniques and they have great potential for diagnostic applications. Thanks to the so-called soft ionization, direct analysis of a wide variety of compound classes can be used for rapid profiling. Lipids are a diverse group of metabolites that share a common feature of having a hydrophobic fragment. They play an important role in various cellular processes. Changes in lipidome correlate with the symptoms of various diseases. The observation of abnormalities in lipid metabolism is especially important in cancers diagnosed in many patients - such as prostate cancer. Monitoring the level of key biomarkers in the development of a given disease will allow for an earlier correct diagnosis and the use of individual treatment. This short review presents the issues of prostate cancer and the applicability of laser desorption/ionization techniques to identify lipid biomarkers that can be used for rapid identification.
9
Content available Surowce roślinne i produkty naturalne : nowe nadzieje dla przyszłych pokoleń
Ligor Magdalena, Rafińska Katarzyna, Wrona Olga, Kiełbasa Anna, Krakowska-Sieprawska Aneta, Buszewski Bogusław
Wiadomości Chemiczne
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2021
|
[Z] 75, 7-8
961--980
EN
The one of the many scientific tasks carried out in Department of Environmental Chemistry and Bioanalytics is the development of methodologies concern antioxidant properties and biological activity of compounds (mainly cyclitols, fatty acids, flavonoids, polyphenolic acids and saponins) separated from raw plant materials and natural products. Such investigations, in general important for human health, was carried out as part of the project entitled: Cultivated plants and natural products as a source of biologically active substances assign to the production of cosmetic and pharmaceutical products as well as diet supplements, attributed by the National Center for Research and Development (2016-2021). The aim of the project was to develop a strategy for the comprehensive use of native plant materials and dissemination of valuable herbal plants in various industries, with particular emphasis on cosmetics, medical devices, dietary supplements, and as livestock feed and a source of biomass. Another important aspect was/is the use of the local potential of plant cultivation, taking into account the Polish production of plant material (limitation of import). Selected plant materials will be both nutritional value and the presence of biologically active ingredients, as well as treating the plant biomass as a renewable source of energy. The proposed technological solutions are located in the area of "green chemistry", an important aspect for the proecology. The plant materials which meet the aforementioned criteria and due to the presence of important active ingredients are: lucerne (Medicago sativa L.), liquorice (Glycyrrhiza glabra), Lepidium sativum and goldenrod (Solidago sp.), buckwheat (Fagopyrum esculentum), fenugreek (Trigonella foenum-graecum), rape and kale, lacy phacelia, (Phacelia tanacetifolia Benth.) as well as camelina (Cornelina sativa L.). An implementation of the proposed research project was proceeded in different directions, based on the cooperation of research institutions with cosmetics and pharmaceutical industries, herbs and beekeepers from across Poland.
10
Content available Propozycje innowacyjnych sorbentów w przygotowaniu próbek biologicznych
Pajewska-Szmyt Martyna, Gadzała-Kopciuch Renata, Buszewski Bogusław
Wiadomości Chemiczne
|
2021
|
[Z] 75, 7-8
1075--1088
EN
The sample preparation stage is a critical step in the whole analytical procedure as it often determines the efficiency of the process. What is particularly noticeable in the area of biological samples. Blood, milk, urine, saliva or tissue are only few examples of complicated biological matrix, that require a optimization of sample pre-treatment method for particular analytes. For these purpose, the aim of following chapter was to characterized main problems with sample preparation method as well as highlighted some innovative ways how to improve sample preparation stage. Attention was particularly focused on the use of dispersive solid phase extraction (dSPE), which has achieved high growth in interest in recent years, mainly due to the simplicity and rapidity of performance. This method is not only used with commercially available sorbents, but also provides a basis for trying to apply new analytical tools for separation of analytes from matrix. Following the trends of nanotechnology and within the rules of green analytical chemistry, scientists are facing the challenges of determining and identifying compounds from various chemical groups. Frequently targeting analytes at trace concentration levels as well biological samples. In addition, attention is also focused on reagents reduction and shorter analysis time but also in terms of minimization of sample volume, which should to be collected. Herein the chapter presented describes exemplary new proposals in sorbents such as molecularly imprinted polymers (MIPs), supported ionic liquids (ILs), dendrimers and metal-organic framework (MOFs). In addition, it also looked at the potential use of magnetic nanoparticles as carriers. New sorbents in sample preparation together with modem instrumental techniques therefore allow the development of a procedure that will be characterized by high selectivity and specificity.
11
Content available Oddech codzienny
Ligor Tomasz, Rudnicka Joanna, Ratiu Ileana Andreea, Monedeiro Fernanda, Monedeiro-Milanowski Maciej, Buszewski Bogusław
Wiadomości Chemiczne
|
2021
|
[Z] 75, 7-8
911--922
EN
The odor of human body has facilitated diagnosis for a long time. Sniffing the body, breath, urine and even feces became one of the useful methods in ancient medicine. For centuries, the sweet smell of the breath was associated with diabetes, the fishy smell was associated with liver disease, measles was associated with the smell of feathers, typhoid with the smell of fresh bread, and tuberculosis with stale beer. Hippocrates also linked the smell of the human body and disease, claiming that the smell of a sick person is different from that of a healthy one. He classified the characteristic odors of the body into sweet, musty, fishy and rotten. The father of chemical analysis of breath was Antonie Lavoisier, who found that carbon dioxide is exhaled by guinea pigs. The pioneer of modem breath analysis was Linus Pauling, who in 1971 presented the results of breath studies using gas chromatography (GC), showing the presence of over 200 substances. Exhaled air containing approximately 78% N2, 17% OSub>2, 3% CO2 and up to 6% water vapor. The exact concentrations of individual inorganic gases depend on many factors, mainly physical exercise, cardiac output, and lung ventilation. A mixture of many volatile organic compounds is a much smaller group of substances at concentrations 100 ppm. The substances in the breath can come from human metabolism and enter into the body by inhaled air and food. Volatile organic compounds present in the breath that can be divided into different chemical classes e.g. saturated hydrocarbons (ethane, pentane, aldehydes), unsaturated hydrocarbons (isoprene), ketones (acetone), sulfur-containing compounds (methyl mercaptan, dimethyl sulfide, dimethyl disulphide, carbon disulphide, carbonyl sulphide) and containing nitrogen (amines). Endogenous substances in the breath can be used to track physiological and pathological processes in the body. Chemical analysis of the breath can provide information regarding biochemical processes in the organism and human health. Compared to many medical diagnostic methods, it is painless, non-invasive and safe. Nowadays, the main purpose of breath analysis is to identify volatile organic compounds that can be used as markers of various diseases. Research focused on detection of lung cancer based on specific volatile organic compounds in the exhaled air is carried out in many laboratories. Rapid and non-invasive methods for early detection of lung cancer and chronic obstructive pulmonary disease is crucial for early diagnosis. This mini review presents background of breath, briefly describes main volatiles, their biochemical origin as well as potential application of exhaled gases analysis.
12
Content available Nowe kierunki badań i wyzwania w analizie leków heparynowych
Sadowski Radosław, Krysztofiak Dominika, Gadzała-Kopciuch Renata, Buszewski Bogusław
Wiadomości Chemiczne
|
2021
|
[Z] 75, 7-8
935--942
EN
The complexity of the structure of heparin anticoagulants requires appropriate sample preparation to be able to perform the analysis correctly. This stage of the analytical procedure is the most time-consuming and has a key impact on the obtained information. Therefore, it is important to improve the current and search for new solutions for the preparation of samples of anticoagulants as well as the separation and identification of components of such drugs. This paper discusses heparin drugs and new research directions and challenges related to the analytics of heparin anticoagulants.
13
Content available Kapilarne ogniskowanie izoelektryczne w analizie białek mleka
Janiszewska Daria, Szultka-Młyńska Małgorzata, Pomastowski Paweł, Buszewski Bogusław
Wiadomości Chemiczne
|
2021
|
[Z] 75, 7-8
943--957
EN
The analysis of milk and dairy products is essential during production, quality control, and understanding the factors that cause food allergies. Milk is one of many examples of biocolloids. Numerous studies show that capillary electrophoresis and capillary isoelectric focusing is an excellent tool for this type of analysis. In addition, the coupling of these techniques with other analytical methods such as MALDI-TOF MS or ESI-MS enables the improvement of the quality of analyzes, allows the separation of proteins close to the isoelectric point values. This short overview summarizes the possibilities of using electromigration techniques in the proteomic and microbiological analysis of milk and milk products.
14
Content available remote Nowe spojrzenie na proces technologiczny produktów mleczarskich : otrzymywanie i charakterystyka masła
Rudnicka Joanna, Pomastowski Paweł, Rafińska Katarzyna, Białczak Dorota, Adamczak Marek, Buszewski Bogusław
Przemysł Chemiczny
|
2021
|
T. 100, nr 4
321--332
PL
Omówiono skład chemiczny masła oraz proces jego produkcji. Zwrócono uwagę na możliwość zwiększenia jego właściwości prozdrowotnych poprzez biosyntezę witaminy D dzięki kulturom bakterii probiotycznych. Omówiono także metody oznaczania wybranych składników masła, jak również obecnych w nim zanieczyszczeń.
EN
A review, with 64 refs., of the chem. compn. of butter and methods of its anal. as well as the possibility of increasing its pro-health properties through the biosynthesis of vitamin D by probiotic bacteria cultures. Methods for detg. selected ingredients present in butter and impurities was also discussed.
15
Content available remote 3D Ornamentowane zdefiniowane struktury krzemionkowe otrzymane przez okrzemki
Brzozowska Weronika, Wojtczak Izabela, Sprynskyy Myroslav, Buszewski Bogusław
Przemysł Chemiczny
|
2021
|
T. 100, nr 3
263--267
PL
Zaprezentowano zwięzłą charakterystykę okrzemek z podaniem możliwości ich aplikacji w różnych gałęziach przemysłu.
EN
A review, with 54 refs., of propertions and methods for prod. of SiO₂ structures under lab. and pilot plant conditions.
16
Nowe podejście w bioanalityce związków bioaktywnych na bazie krzemu
Szultka-Młyńska Małgorzata, Orzoł Aleksandra, Rogowska Agnieszka, Gołębiowski Adrian, Głowacka Katarzyna, Pomastowski Paweł, Górecki Ryszard, Buszewski Bogusław
Analityka : nauka i praktyka
|
2021
|
nr 4
4--13
PL
Rośliny lecznicze stanowią niedoceniany rezerwuar bioaktywnych substancji antybakteryjnych, antygrzybicznych i antypasożytniczych. Prowadzenie kompleksowych i systematycznych badań w zakresie identyfikacji oraz izolacji tych substancji stanowi wyzwanie dla współczesnej nauki.
17
Nowe materiały na bazie 3D biokrzemionki
Al Saoud Hussam, Krakowska-Sieprawska Aneta, Sprynskyy Myroslav, Pomastowski Paweł, Buszewski Bogusław
Analityka : nauka i praktyka
|
2021
|
nr 3
4--12
PL
Biokrzemionka, jako niedrogi, przyjazny dla środowiska i łatwo dostępny naturalny biomateriał, uzupełnia technologię syntetycznych mezoporowatych materiałów krzemionkowych.
18
Nano- i mikroplastiki w ekosystemie wodnym
Szultka-Młyńska Małgorzata, Pashaei Reza, Dzingelevičienė Reda, Buszewski Bogusław
Analityka : nauka i praktyka
|
2021
|
nr 2
52--57
PL
Wpływ plastiku na organizmy wodne, biorąc pod uwagę ich wszechobecność w środowisku wodnym (jeziora, rzeki, morza, oceany), budzi coraz większe obawy. Zauważalny jest postęp badań naukowych w tym kierunku, ale są one wciąż bardzo fragmentaryczne.
19
Multimodalne obrazowanie termograficzne w diagnostyce medycznej
Karwowski Wojciech, Skórski Jarosław, Kłodzińska Ewa, Sroka Ryszard, Buszewski Bogusław
Analityka : nauka i praktyka
|
2021
|
nr 4
30--33
PL
Przedstawione w niniejszym artykule nowe podejście do rejestracji obrazu łączy dwie zupełnie różne modalności obrazów medycznych w podczerwieni: obrazy termowizyjne najcieplejszych miejsc izolowanych i miejsc najzimniejszych.
20
Mleko kobiece - nowe rozwiązania analityczne w badaniach nad zanieczyszczeniami oraz substancjami biologicznie aktywnymi
Pajewska-Szmyt Martyna, Gadzała-Kopciuch Renata, Buszewski Bogusław
Analityka : nauka i praktyka
|
2021
|
nr 4
14--17
PL
Artykuł na podstawie rozprawy doktorskiej pt.: 'Wpływ zanieczyszczeń środowiskowych na jakość mleka matki. Opracowanie innowacyjnych sorbentów i kropek kwantowych jako narzędzie analityczne w przygotowaniu próbek' nagrodzonej przez Komitet Chemii Analitycznej PAN w 2021 roku w konkursie na najlepsze prace doktorskie, nagroda ufundowana przez firmę Perlan Technologies.
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