Wyniki wyszukiwania - BazTech

Ograniczanie wyników

2 Acta Chromatographica

Znaleziono wyników: 2

Liczba wyników na stronie

Wyniki wyszukiwania

Sortuj według:

Ogranicz wyniki do:

HPLC monitoring of the microsomal stability of rutin and quercetin

Szőke É, Petroianu G., Tekes K., Benkő B, Szegi P., Laufer R., Veress G

Acta Chromatographica

2009

Vol. 21, no. 3

399--410

Reversed-phase HPLC has been used to monitor the concentration of the two major Chamomile components rutin and quercetin during rat liver microsomal treatment. The possibility of microsomal oxidative metabolism or stability of these two components was examined using a guard-column without any clean-up. The concentration of quercetin decreased when exposed to rat liver microsomal media whereas the rutin concentration did not change significantly over one hour of treatment.

HPLC analysis of microsomal metabolism of K-48

Benkő B., Laufer R., Ohmacht R.

Acta Chromatographica

2007

No. 19

61-72

K-27 and K-48, bisquaternary pyridinium aldoximes differing only in the number of methyl units in the alkyl bridges between the two quaternary nitrogen atoms, are promising candidates for use as potent and effective antidotes to organophosphate intoxication. K-27 and K-48 were treated with rat hepatic microsomal preparations from healthy (control) and diabetic animals. Microsomal metabolism was measured at different times up to 45 min. This treatment resulted in a decrease of approximately 30% in the concentration of K-48 whereas that of K-27 was unchanged. There was no significant difference between the effects of microsomal preparations from control and diabetic rat liver. K-27 and K-48 in a variety of media were analysed by reversed-phase HPLC with both ultraviolet and electrochemical detection. The method was validated by the usual procedures.