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2 Wiadomości Chemiczne

2 2019

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Związki wanadu i chromu jako potencjalne insulino-mime tyki wykorzystywane w leczeniu cukrzycy

Drzeżdżon Joanna, Malinowski Jacek, Zych Dominika, Jacewicz Dagmara

Wiadomości Chemiczne

2019

[Z] 73, 11-12

753--775

The report focuses on the antidiabetic, also termed insulin-like, effect of various vanadium and chromium derivatives, proposed mechanisms of their activity, their use in in vivo and in vitro studies, as well as in diabetic patients, their toxicity and effectiveness in controlling clinical signs of diabetes. Studies indicate that compounds of vanadium and chromium is necessary for regulation of carbohydrate and lipid metabolism mainly due to increasing the number of insulin receptors and its activation by phosphorylation. Some authors believe that compounds of chromium(III) deficiency can lead to glucose intolerance and symptoms of type 2 diabetes. However, due to methodological limitations of many clinical studies, the statements of major diabetes associations concerning recommendation of various vanadium and chromium derivatives supplementation in individuals with diabetes and obesity still remains negative. Additional studies are urgently needed to elucidate the mechanism of action of chromium and vanadium compounds and its role in the prevention and control of diabetes.

Zastosowanie polikarboksylanowych związków kompleksowych w tworzeniu sieci metaloorganicznych typu MOF

Zych Dominika, Drzeżdżon Joanna, Jacewicz Dagmara, Chmurzyński Lech

Wiadomości Chemiczne

2019

[Z] 73, 5-6

401--423

The first research on Coordination Polymers began at the beginning of the 20th century. Wider understanding of their structure has enabled the development of crystallography. Since then compounds, which belong to this group, have been the subject of broad-spectrum scientific research. A particular class of these compounds, known relatively recently, are Metal–Organic Frameworks (MOF). The MOF structure is based on negatively charged organic linkers, e.g. polycarboxylic anions connected to various metal cations or metal clusters. MOFs are mainly built up from metal cations: transition, alkaline earth, main groups of the periodic table, as well as rare earth metals. Moreover, organic ligands used in the construction of MOF materials should contain electron donors. A characteristic bond, that allows the formation of hybrids, through the interactions of nodes and bridges is the coordination bond. It allows to synthesize a three-dimensional framework structure. Modern synthesis leads to the generation of porous materials with a very large surface area of pores and unique properties. Considering their synthesis, crystalline structures and physicochemical properties of MOF, as well as broad MOFs applications including gas storage, separation, catalysts, luminescence, magnetism and others, it is reasonable to state that MOFs can be used in many areas, not only in science, but also in environmental protection and in industry, for example, energy industry, chemical and biochemical industry.