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In vitro assay of the biological activity of bisphosphonates

Chmielewska E., Miszczyk P., Kafarski P., Kempińska K., Wietrzyk J.

Interdisciplinary Journal of Engineering Sciences

2014

Vol. 2, no. 1

13--16

Nowadays, the use of bisphosphonates are the gold standard of treatment of bone diseases. Due to the high utility of these compounds, scientists still search for better and better structures, with a variety of substituents at carbon’s atom and create new libraries or improve methods of their synthesis. To determine the potential effect of newly discovered bisphosphonates, for example antiosteoporotic activity, there are in vitro tests which allow to determine the half maximal inhibitory concentrations (IC50) of cells. This paper describes in detail the methodology for test the biological activity of bisphosphonates. Shows the results of biological activity for synthesized bisphosphonates in relation to the commercial-incadronate and zoledronate.