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Early effect of thalamotomy on cognitive function in patients with Parkinson’s disease

Gorzelańczyk E. J., Ackermann-Szulgit D., Kunc M., Harat M., Walecki P.

Bio-Algorithms and Med-Systems

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2018

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Vol. 14, no. 1

art. no. 20180005

EN

Thalamotomy is a neurosurgical procedure used in the treatment of advanced Parkinson’s disease (PD). The aim of our research is to evaluate the early impact of a lesion in the ventrointermedial nucleus (VIM) of the thalamus on cognitive and motor function in people with PD. Sixty patients who qualified for right- or leftsided VIM thalamotomy were involved in the study. The cognitive and motor functions of each patient were assessed both prior to and following the surgical procedure. Twenty-nine PD patients without ablative treatment were qualified for the comparison group, and 57 neurologically healthy individuals were assigned to the control group. The following tests were carried out: Mini Mental State Examination, Benton Visual Retention Test, Stroop Color and Word Test, Trail Making Test A&B, and Rey Auditory Verbal Learning Test. Statistically significant differences were found in reaction time, visual-spatial working memory, auditory-verbal memory, and overall level of cognitive function when comparing the results of tests carried out before and after thalamotomy and when comparing patients who had undergone surgery with untreated or healthy individuals. In patients with right-sided and left-sided thalamotomy differences were also found in the mean number of perseverative errors and recalled words.

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Computer-based system to capture, collect, process and analyze data in psychomotor tests

Faron P., Lasoń W., Walecki P., Kunc M., Gorzelańczyk E. J.

Bio-Algorithms and Med-Systems

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2013

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Vol. 9, no. 3

147--154

EN

The article explains the principles and goals in creating a computer-based system for the measurement of psychomotor functioning, its functionality, and user interface. To illustrate the capabilities of the system, the results of analysis of the selected psychomotor tests performed in different groups of patients are presented. The usefulness of the presented tool in the quantitative study of psychomotor functioning is assessed.

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Analysis of tremor in motor learning task

Walecki P., Lasoń W., Kunc M., Gorzelańczyk E. J.

Bio-Algorithms and Med-Systems

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2013

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Vol. 9, no. 1

45--52

EN

Hand-eye coordination is required in many skilled tasks. Individual differences affect the performance of people at work and leisure, for example, during assembly jobs or sports. The aim of this study was to determine whether motor learning can change the physiological action of hand tremor. Tremor is a repetitive and stereotyped movement, with regular frequency and amplitude, but there are different types of tremors with pattern variation. The results were calculated by participants’ time-on and time-off the target, the average distance from the center of the target, and the frequency of oscillatory movement of a cursor (tremor). The results of this study indicate a statistically significant (p<0.05) influence of effect of task repetition on improvement of motor control and reduction of a high-amplitude tremor and an increase of a low-amplitude tremor. The assessed individuals achieved more than 50% better outcomes of a hand-eye coordination task in the final trials when compared with the initial trials. The dynamics of motor learning tend to rise, with a steady level of a 1-h interval between trials.

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State Complexity of Union and Intersection for Two-Way Nondeterministic Finite Automata

Kunc M., Okhotin A.

Fundamenta Informaticae

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2011

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Vol. 110, nr 1-4

231-239

EN

The number of states in a two-way nondeterministic finite automaton (2NFA) needed to represent the intersection of languages given by an m-state 2NFA and an n-state 2NFA is shown to be at least m + n and at most m + n + 1. For the union operation, the number of states is exactly m + n. The lower bound is established for languages over a one-letter alphabet. The key point of the argument is the following number-theoretic lemma: for all m, n > 2 with m, n 6≈6 (and with finitely many other exceptions), there exist partitionsm = p1+. . .+pk and n = q1+. . .+ql, where all numbers p1, . . . , pk, q1, . . . , ql > 2 are powers of pairwise distinct primes. For completeness, an analogous statement about partitions of any two numbers m, n∉ {4, 6} (with a fewmore exceptions) into sums of pairwise distinct primes is established as well. Keywords: Finite automata, two-way automata, state complexity, partitions into sums of primes.

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Digitalized drawing test (DDT) – the tool for an early subclinical motor symptoms diagnosis

Gorzelańczyk E. J., Włodarczyk K., Laskowska E., Kunc M., Jelonek J.

Bio-Algorithms and Med-Systems

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2008

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Vol. 4, no. 8

93--99

EN

Motor functioning is linked with cortico-subcortical circuits and can be the biological marker of some disorders. Motor and tension disorders of specific muscles can be monitored during drawing test completion. The advantage of computer aided tests is that they allow to perform mathematical and statistical analysis. By analyzing primary movements parameters and spectrograms of hand tremor during a drawing test, the researcher obtains a diagnostic data set. A digitalized drawing test consists of a pattern (designed by Edward Jacek Gorzelańczyk) on a piece of paper with special figures. Each shape is of diagnostic value for certain motor abilities (precise movement, muscle tone, kinetics of whole hand/arm). A PC digital tablet with an electro-magnetic ballpen allows to register digital data during the test. The application Med Tablet, co-designed by the author of this article, is used to store and analyze the obtained data. Alcohol or other psychoactive substance addiction gives specific tremors that can be observed in a momentary velocity profile. The profile can also contribute to Parkinson’s disease or intention tremor distinction. What is more, motor disorders can be diagnosed in the preclinic phase of the disease. This digitalized drawing test was also used to evaluate the level of thalamotomy or pallidotomy. A tremor affecting any area of the body is transmitted to hand during the drawing task. Digitalized drawing test can become a subclinical motor symptoms diagnostic tool in PD, addiction and motor dysfunctions in other diseases.